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Description of key information

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

During the literature search and data gap analysis it became obvious that the overall database on substance-specific human health hazard data for triiron bis(orthophosphate) is too scant to cover all REACH endpoints. Therefore, the remaining data gaps had to be covered by either experimental testing or read-across from similar substances.

Selected endpoints for the human health hazard assessment are addressed by read-across, using a combination of data on the phosphate moiety and the iron moiety (or one of its readily soluble salts). This way forward is acceptable, since triiron bis(orthophosphate) dissociates to the phosphate anion and the iron cation upon dissolution in aqueous media.

Once the individual constituents of triiron bis(orthophosphate) become bioavailable (i.e. in the acidic environment in the gastric passage or after phagocytosis by pulmonary macrophages), the “overall” toxicity of the dissociated substance can be described by the toxicity of the “individual” constituents. Since synergistic effects are not expected, the human health hazard assessment consists of an individual assessment of the iron cation and the phosphate anion.

The hazard information of the individual constituents was obtained from publicly available literature (i.e. EFSA documents, WHO documents).

Triiron bis(orthophosphate) readily dissociates to the corresponding iron cations and phosphate anions. The iron cation and the phosphate anion are considered to represent the overall toxicity of triiron bis(orthophosphate) in a manner proportionate to the phosphate and the metal (represented by one of its readily soluble salts). Based on the above information, unrestricted read-across is considered feasible and justified.