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EC number: 274-695-6 | CAS number: 70609-66-4
Endpoint summary
Administrative data
Description of key information
Short-term toxicity to fish
On the basis of EPI suite, ECOSAR version 1.1, the LC50 value for short term toxicity to fish was predicted to be 722.57 mg/l for sodium 2-[(1-oxododecyl)amino]ethanesulphonate (CAS: 70609-66-4) in 96 hrs. Based on the LC50 value, it can be concluded that the substance sodium 2-[(1-oxododecyl)amino]ethanesulphonate (CAS: 70609-66-4) can be considered as not toxic to aquatic environment and thus can be considered as “not classified” as per the CLP criteria.
Short-term toxicity to aquatic invertebrates
Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the closest read across substances, the toxicity on invertebrate was predicted sodium 2-[(1-oxododecyl)amino]ethanesulphonate (CAS: 70609-66-4). Effect concentration i.e EC50 value was estimated to be 427.09 mg/l for Daphnia magna for 48 hrs duration. It was concluded that the sodium 2-[(1-oxododecyl)amino]ethanesulphonate (CAS: 70609-66-4) was likely to be not toxic to aquatic invertebrate.
Toxicity to aquatic algae and cyanobacteria
Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the closest read across substances, the short term toxicity on aquatic algae predicted for sodium 2-[(1-oxododecyl)amino]ethanesulphonate (CAS: 70609-66-4). Effect concentration i.e EC50 value estimated to be 139.54 mg/l for Desmodesmus subspicatus for 48 hrs duration. It can be concluded that the sodium 2-[(1-oxododecyl)amino]ethanesulphonate (CAS: 70609-66-4) IS likely to be not toxic to aquatic algae, hence it can be considered to be “not classified” as per the CLP classification criteria for aquatic environment.
Toxicity to micro-organisms
Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the closest read across substances, the short term toxicity on micro-organism predicted for sodium 2-[(1-oxododecyl)amino]ethanesulphonate (CAS: 70609-66-4). Effect concentration i.e IGC50 value estimated to be 5813.18 mg/l for Tetrahymena pyriformis for 48 hrs duration. It can be concluded that the sodium 2-[(1-oxododecyl)amino]ethanesulphonate (CAS: 70609-66-4) IS likely to be not toxic to micro-organism, hence it can be considered to be “not classified” as per the CLP classification criteria for aquatic environment.
Additional information
Short-term toxicity to fish
On the basis of EPI suite, ECOSAR version 1.1, the LC50 value for short term toxicity to fish was predicted to be 722.57 mg/l for sodium 2-[(1-oxododecyl)amino]ethanesulphonate (CAS: 70609-66-4) in 96 hrs. Based on the LC50 value, it can be concluded that the substance sodium 2-[(1-oxododecyl)amino]ethanesulphonate (CAS: 70609-66-4) can be considered as not toxic to aquatic environment and thus can be considered as “not classified” as per the CLP criteria.
Short-term toxicity to aquatic invertebrates
Following studies include the predicted data and experimental study for the target chemical and structurally similar read across to conclude the
sodium 2-[(1-oxododecyl)amino]ethanesulphonate (CAS: 70609-66 -4)toxicity towards aquatic invertebrate is summarized as follows:-
Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the closest read across substances, the toxicity on invertebrate was predicted sodium 2-[(1-oxododecyl)amino]ethanesulphonate (CAS: 70609-66-4). Effect concentration i.e EC50 value was estimated to be 427.09 mg/l for Daphnia magna for 48 hrs duration. It was concluded that the sodium 2-[(1-oxododecyl)amino]ethanesulphonate (CAS: 70609-66-4) was likely to be not toxic to aquatic invertebrate, hence it can be considered to be “not Classified” as per the CLP classification criteria for aquatic environment.
Similar prediction by EPI suite, ECOSAR version 1.1, On the basis of EPI suite, ECOSAR version 1.1, the EC50 value for toxicity to aquatic invertebrate was predicted to be 391.47 mg/l for sodium 2-[(1-oxododecyl)amino]ethanesulphonate(CAS: 70609-66-4) in 48 hrs. Based on the EC50 value, it can be concluded that the substance sodium 2-[(1-oxododecyl)amino]ethanesulphonate(CAS: 70609-66-4) is toxic to the aquatic invertebrate and can be considered as“not classified”as per CLP regulation.
The above predicted data of traget chemical is supported by the experimental study ofstructurally similar read acrossSodium dodecane-1-sulphonate(CAS: 2386-53-0) from publication Water Research 1978, suggests that the
Short-term toxicity to aquatic invertebrates test was carried out for24 Hourto study the Sodium dodecane-1-sulphonate on aquatic invertebrate. Mobility effect was measured during the test. Effective concentration EC50 to 50% of 5 Daphnia magna at 24 hrs IS 220 mg/l. It can be concluded that the Sodium dodecane-1-sulphonate is not toxic to the aquatic invertebrate.
Similar supporting experimental study for anotherstructurally similar read acrossε-caprolactam (CAS:105-60-2) from J-Check (Japan Chemical Collaborative Knowledge Database) indicates that the Short-term toxicity to aquatic invertebrates test was carried out according to the OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test) to study the effects of ε-caprolactam on aquatic invertebrate.
The effective concentration EC50 to Daphnia magna in 48 h is >1000 mg/L. Immobilisation effects was measured during the test. It can be concluded that the ε-caprolactam is not toxic to the aquatic invertebrate.
Thus based on the effect concentrations which is in the range 220 mg/l to >1000 mg/Lgive the conclusion that test substance sodium 2-[(1-oxododecyl)amino]ethanesulphonate (CAS: 70609-66 -4) is likely to be not toxic to aquatic invertebrate at environmentally relevant concentrations and applying the weight of evidence approach it can be considered to be“not classified”as per the CLP classification criteria.
Toxicity to aquatic algae and cyanobacteria
Following studies include the predicted data and experimental study for the target chemical and structurally similar read across to conclude the toxicity extent of sodium 2-[(1 oxododecyl)amino]ethanesulphonate (CAS: 70609-66-4) towards aquatic algae is summarized as follows:
Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the closest read across substances, the short term toxicity on aquatic algae predicted for sodium 2-[(1-oxododecyl)amino]ethanesulphonate (CAS: 70609-66-4). Effect concentration i.e EC50 value estimated to be 139.54 mg/l for Desmodesmus subspicatus for 48 hrs duration. It can be concluded that the sodium 2-[(1-oxododecyl)amino]ethanesulphonate (CAS: 70609-66-4) IS likely to be not toxic to aquatic algae, hence it can be considered to be “not classified” as per the CLP classification criteria for aquatic environment.
Another predicted data for target chemical indicates that On the basis of EPI suite, ECOSAR version 1.1, the EC50 value for toxicity to aquatic algae was predicted to be 240.17 mg/l for sodium 2-[(1-oxododecyl)amino]ethanesulphonate (CAS: 70609-66-4) in 48 hrs. Based on the EC50 value, it can be concluded that the substance sodium 2-[(1-oxododecyl)amino]ethanesulphonate (CAS: 70609-66-4) can be considered as not toxic to aquatic environment.
The above predicted data is supported by the experimental study ofstructurally similar read acrossDodecane-12-lactam (CAS:947-04-6) from J-Check 1998,Toxicity to aquatic algae and cyanobacteria test was carried out to study the effects of Dodecane-12-lactam on aquatic invertebrate. Growth rate effects was measured.The effective concentration EC50 to 50% of green algae is > 100 mg/l at 72 hrs. It can be concluded that the Dodecane-12-lactam is not toxic to the aquatic environment.
Thus based on the effect concentrations which is in the range > 100 mg/l to 240.17 mg/l give the conclusion that test substance sodium 2-[(1 oxododecyl)amino]ethanesulphonate (CAS: 70609-66-4) was likely to be not toxic to aquatic algae at environmentally relevant concentrations and applying weight of evidence approach it can be considered to be“not classified”as per the CLP classification criteria.
Toxicity to micro-organisms
Following studies include the predicted data and experimental study for the target chemical and structurally similar read across to conclude the toxicity extent of sodium 2-[(1 oxododecyl)amino]ethanesulphonate (CAS: 70609-66-4) towards micro-organisms is summarized as follows:
Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the closest read across substances, the short term toxicity on micro-organism predicted for sodium 2-[(1-oxododecyl)amino]ethanesulphonate (CAS: 70609-66-4). Effect concentration i.e IGC50 value estimated to be 5813.18 mg/l for Tetrahymena pyriformis for 48 hrs duration. It can be concluded that the sodium 2-[(1-oxododecyl)amino]ethanesulphonate (CAS: 70609-66-4) IS likely to be not toxic to micro-organism, hence it can be considered to be “not classified” as per the CLP classification criteria for aquatic environment.
The above predicted data of target chemical is supported by the experimental study ofstructurally similar read across2-pyridone (CAS:142-08 -5) from the publication Ecotoxicology and Environmental Safety, 1987, suggests that the Toxicity to microorganisms test was carried out to study the effects of 2-pyridone in aquatic micro-organism. The effective concentration EC50 to 50% of Tetrahymena pyriformis at 60 hr is 3877.2 mg/l. Growth rate effects was measured during the test. It can be concluded that the2-pyridone is not toxic to the aquatic environment.
Furhter it is supported by the experimental study for anotherstructurally similar read acrossParacetamol (CAS: 103-90-2) from publication The Science of the Total Environment 1991 indicates, that the Toxicity to micro-organisms test was carried out to study the effects of Paracetamol on micro-organisms. The inhibition growth concentration (IGC50) to 50% of microorganism (Tetrahymena pyriformis) in a 48 hr for Paracetamol is 999 mg/L. It can be concluded from the value that the Paracetamol is not toxic to the aquatic environment.
Thus based on the effect concentrations which is in the range 999 mg/l to5813.18 mg/lgive the conclusion that test substancesodium 2-[(1 oxododecyl)amino]ethanesulphonate (CAS: 70609-66-4)is likely to be non-toxic to micro-organisms at environmentally relevant concentrations and applying weight of evidence approach it can be considered to be “not classified” as per the CLP classification criteria.
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