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EC number: 216-032-5 | CAS number: 1477-55-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- not stated
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- TK 11813 was applied to a shaved area of approximately 60 square cm on the backs of rats and the animals were observed until necropsy on day 14
- GLP compliance:
- no
- Remarks:
- study predates GLP
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- m-phenylenebis(methylamine)
- EC Number:
- 216-032-5
- EC Name:
- m-phenylenebis(methylamine)
- Cas Number:
- 1477-55-0
- Molecular formula:
- C8H12N2
- IUPAC Name:
- 1-[3-(aminomethyl)phenyl]methanamine
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): TK 11813
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Tif RAIf (SPF) random bred
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Ciba-Geigy, Basle, Switzerland
- Weight at study initiation: 180-200 g
- Housing: Individually in Macrolon cages (type 2)
- Diet: NAFAG, Gossau SG rat food ad libitum
- Water: Ad libitum
- Acclimation period: Minimum of 4 days
ENVIRONMENTAL CONDITIONS
- Temperature: 22 ± 1 degrees Centigrade
- Humidity: 55 ± 5 %
- Photoperiod: 14 hours light
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Approximately 24 hours before treatment, an area on the back of the rats of approximately 60 square cm was shaved with an electric clipper. The substance was then evenly dispersed on the skin with a syringe and was covered with an occlusive dressing, which was fastened round the trunk with an adhesive elastic bandage. After 24 hours, the dressing was removed, the skin cleaned with lukewarm water and the reaction of the skin was appraised.
- Duration of exposure:
- 24 hours
- Doses:
- 2150 mg/kg and 3170 mg/kg
- No. of animals per sex per dose:
- 3 males and 3 females
- Control animals:
- no
- Details on study design:
- No data
- Statistics:
- No data
Results and discussion
- Preliminary study:
- No data
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 100 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: TK 11813 is described only as a concentrate in the study report and no information is available on the percentage of m-phenylenebis(methylamine)
- Mortality:
- See Table 1 (below)
- Clinical signs:
- other: Within 24 hours after treatment, the rats in both dosage groups showed dyspnoea, curved position and ruffled fur. Five to seven days after treatment, a severe erythema developed into necrosis. The animals recovered from systemic symptoms within 9 to 13 da
- Gross pathology:
- No substance related gross organ changes were seen
- Other findings:
- No data
Any other information on results incl. tables
Table 1 - Rate of deaths
Dose (mg/kg) |
Concentration % of formulation |
Number of animals |
Died within |
||||||||||
1 h |
24 h |
48 h |
7 d |
14 d |
|||||||||
♂ |
♀ |
♂ |
♀ |
♂ |
♀ |
♂ |
♀ |
♂ |
♀ |
♂ |
♀ |
||
2150 |
conc |
3 |
3 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
3170 |
conc |
3 |
3 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
No higher doses were possible |
Applicant's summary and conclusion
- Conclusions:
- The acute LD50 of TK 11813 in rats of both sexes observed over a period of 14 days is greater than 3100 mg/kg. The substance therefore has a slight acute toxicity to the rat by this route of administration.
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