Registration Dossier
Registration Dossier
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EC number: 219-411-3 | CAS number: 2432-87-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer reviewed journals
Data source
Reference
- Reference Type:
- publication
- Title:
- Final Safety Assessment of Thiodipropionic Acid and Its Dialkyl Esters as Used in Cosmetics
- Author:
- Catherine Diamante, Monice Zondlo Fiume, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, and F. Alan Andersen
- Year:
- 2 010
- Bibliographic source:
- International Journal of Toxicology; 29(Supplement 3), 2010, 137S- 150S
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Modified Draize test
- Principles of method if other than guideline:
- To assess the eye irritation potential of Didodecyl 3,3'-thiodipropionate (Dilauryl thiodipropionate) in rabbits
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Didodecyl 3,3'-thiodipropionate
- EC Number:
- 204-614-1
- EC Name:
- Didodecyl 3,3'-thiodipropionate
- Cas Number:
- 123-28-4
- Molecular formula:
- C30H58O4S
- IUPAC Name:
- didodecyl 3,3'-sulfanediyldipropanoate
- Test material form:
- solid
- Details on test material:
- Name of the test chemical: didodecyl 3,3'-sulfanediyldipropanoate [Dilauryl thiodipropionate]
Molecular Formula:C30H58O4S
Molecular Weight:514.85 g/mol
Substance Type: Organic
Physical State: Solid
Constituent 1
- Specific details on test material used for the study:
- Name of the test chemical: didodecyl 3,3'-sulfanediyldipropanoate [Dilauryl thiodipropionate]
Molecular Formula:C30H58O4S
Molecular Weight:514.85 g/mol
Substance Type: Organic
Physical State: Solid
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: New Zealand Albino
- Details on test animals or tissues and environmental conditions:
- no data available
Test system
- Vehicle:
- other: makeup foundation containing 0.05% Dilauryl thiodipropionate
- Controls:
- not specified
- Amount / concentration applied:
- an unspecified amount of a makeup foundation containing 0.05% Dilauryl thiodipropionate
- Duration of treatment / exposure:
- single exposure
- Observation period (in vivo):
- The rabbits were observed for signs of irritation (duration not mentioned).
- Duration of post- treatment incubation (in vitro):
- no data available
- Number of animals or in vitro replicates:
- 9
- Details on study design:
- no data available
Results and discussion
In vitro
- Other effects / acceptance of results:
- no data available
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: no data available
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- None of the rabbits had ocular reactions to the test material at any of the observation times
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- None of the rabbits had ocular reactions to Dilauryl thiodipropionate at any of the observation times. Hence, the makeup foundation containing 0.05% Dilauryl thiodipropionate was considered not irritating to rabbit eyes under the conditions of the study.
- Executive summary:
The eye irritation potential of Didodecyl 3,3'-thiodipropionate (Dilauryl thiodipropionate) was assessed in rabbits according to Modified Draize method. An unspecified amount of a makeup foundation containing 0.05% Dilauryl thiodipropionate was instilled into the eyes of 9 albino New Zealand White rabbits. The rabbits were observed for signs of irritation (duration not mentioned).
None of the rabbits had ocular reactions to Dilauryl thiodipropionate at any of the observation times. Hence, the makeup foundation containing 0.05% Dilauryl thiodipropionate was considered not irritating to rabbit eyes under the conditions of the study.
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