Registration Dossier
Registration Dossier
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EC number: 219-411-3 | CAS number: 2432-87-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data from handbook
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Acute oral toxicity study in mouse for CAS: 2432-87-3
- Author:
- Michael Bolgar, Jack Hubball, Joseph Groeger, Susan Meronek
- Year:
- 2 015
- Bibliographic source:
- Handbook for the Chemical Analysis of Plastic and Polymer Additives, Second Edition, 2015, Pg 386
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity study of 1,10-dioctyl decanedioate was performed in mouse.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Dioctyl sebacate
- EC Number:
- 219-411-3
- EC Name:
- Dioctyl sebacate
- Cas Number:
- 2432-87-3
- Molecular formula:
- C26H50O4
- IUPAC Name:
- 1,10-dioctyl decanedioate
- Test material form:
- liquid
- Details on test material:
- - Name of the test material: Dioctyl decanedioate / Dioctyl sebacate
- IUPAC name: 1,10-dioctyl decanedioate
- Molecular formula: C26H50O4
- Molecular weight: 426.677g/mol
- Smiles: C(=O)(OCCCCCCCC)CCCCCCCCC(=O)OCCCCCCCC
- Inchi : 1S/C26H50O4/c1-3-5-7-9-15-19-23-29-25(27)21-17-13-11-12-14-18-22-26(28)30-24-20-16-10-8-6-4-2/h3-24H2,1-2H3
- Substance type: Organic
- Physical state : Liquid (colorless to light yellow)
Constituent 1
- Specific details on test material used for the study:
- - Name of the test material: Dioctyl decanedioate / Dioctyl sebacate
- IUPAC name: 1,10-dioctyl decanedioate
- Molecular formula: C26H50O4
- Molecular weight: 426.677g/mol
- Smiles: C(=O)(OCCCCCCCC)CCCCCCCCC(=O)OCCCCCCCC
- Inchi : 1S/C26H50O4/c1-3-5-7-9-15-19-23-29-25(27)21-17-13-11-12-14-18-22-26(28)30-24-20-16-10-8-6-4-2/h3-24H2,1-2H3
- Substance type: Organic
- Physical state : Liquid (colorless to light yellow)
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 9500mg/kg bw
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 9 500 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% Mortality was observed
- Mortality:
- 50% Mortality was observed
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- LD50 was considered to be 9500mg/kg body weight. When mouse was treated with 1,10-dioctyl decanedioate (2432-87-3) orally.
- Executive summary:
Acute oral toxicity study was done in mouse using1,10-dioctyl decanedioate(2432-87-3). 50% mortality was observed at dose 9500mg/kg bw. Hence LD50 was considered to be 9500mg/kgbody weight. When mouse were treated with1,10-dioctyl decanedioate(2432-87-3)orally.
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