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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Reference
Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
Standard bioaccumulation studies are not applicable to petroleum UVCB substances, therefore in accordance with Annex XI Section 1.3 testing is not scientifically necessary and the endpoint has been fulfilled using QSAR calculations for relevant constituents. Full justifications for this QSAR are presented in 'Attached justification as well as in 'Overall remarks and attachments'' section'. In brief these are justified because:
- the results are obtained from a QSAR model whose scientific validity has been established
- petroleum substances fall within the applicability domain of the QSAR model
- results are adequate for the purposes of risk assessment
- adequate and reliable documentation is provided
Qualifier:
no guideline required
Principles of method if other than guideline:
- Software tool(s) used including version: EPISuite v4.10
- Model(s) used: BCFBAF v3.01
- Model description: see field 'Attached justification'
- Justification of QSAR prediction, see field 'Attached justification
GLP compliance:
not specified
Key result
Type:
BCF
Value:
ca. 105 L/kg
Basis:
whole body w.w.
Calculation basis:
steady state
Conclusions:
BCF for Hydrocarbons, C7 -C9, isoalkanes, EC No. 921 -728 -3 is 105 L/kg wet-wt (see Results and discussion section, Bioaccumulation factor).
Executive summary:

Standard bioaccumulation studies are not applicable to petroleum UVCB substances, therefore in accordance with Annex XI Section 1.3 testing is not scientifically necessary and the endpoint has been fulfilled using QSAR calculations for relevant constituents based on BCFBAF v3.01. Full justifications for this QSAR are presented in 'Attached justification' as well as in Overall remarks, attachements section ''Attached full study reporrt''. In brief these are justified because:

- the results are obtained from a QSAR model whose scientific validity has been established

- petroleum substances fall within the applicability domain of the QSAR model

- results are adequate for the purposes of risk assessment

BCF for Hydrocarbons, C7 -C9, isoalkanes, EC No. 921-728-3 is 105 L/kg wet-wt (see Results and discussion section, Bioaccumulation factor).

Description of key information

Standard bioaccumulation studies are not applicable to petroleum UVCB substances, therefore in accordance with Annex XI Section 1.3 testing is not scientifically necessary and the endpoint has been fulfilled using QSAR calculations for relevant constituents based on BCFBAF v3.01.

BCF for Hydrocarbons, C7-C9, isoalkanes is 105 L/kg wet-wt.

Key value for chemical safety assessment

BCF (aquatic species):
105 L/kg ww

Additional information