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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from Secondary source

Data source

Referenceopen allclose all

Reference Type:
other: Authorized database
Title:
Acute oral toxicity of CAS no 105-68-0
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
ChemIDplus A TOXNET DATABASE Lite Browse Advanced, 2017
Reference Type:
publication
Title:
Monographs on Fragrance Raw Materials – Isoamyl Propionate
Author:
D. L. J. Opdyke
Year:
1979
Bibliographic source:
Food and Cosmetics Toxicology, Volume 13, Issue 6, Pages 809-810, 1975.
Reference Type:
secondary source
Title:
SCIENTIFIC LITERATURE REVIEW OF ALIPHATIC PRIMARY ALCOHOLS, ESTERS AND ACIDS IN FLAVOR USAGE Volume I - VII
Author:
Flavor and Extract Manufacturer's Association
Year:
1985
Bibliographic source:
NATIONAL TECHNICAL INFORMATION SERVICE, VoL 1, PB86155926, 1985

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as per mentioned below
Principles of method if other than guideline:
The acute oral LD50 value in rabbits for isoamyl propionate in rabbits
GLP compliance:
not specified
Test type:
other: No data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Isopentyl propionate
EC Number:
203-322-1
EC Name:
Isopentyl propionate
Cas Number:
105-68-0
Molecular formula:
C8H16O2
IUPAC Name:
3-methylbutyl propanoate
Test material form:
not specified
Details on test material:
Name of test material (as cited in study report): Isoamyl propionate
Molecular formula (if other than submission substance): C8H16O2
Molecular weight (if other than submission substance): 144.212 g/mole
Smiles notation (if other than submission substance): C(OCCC(C)C)(CC)=O
InChl (if other than submission substance):
1S/C8H16O2/c148(9)10657(2)3/h7H,46H2,13H3
Substance type: Organic
Physical state: Liquid
Specific details on test material used for the study:
Name of test material (as cited in study report): Isoamyl propionate
Molecular formula (if other than submission substance): C8H16O2
Molecular weight (if other than submission substance): 144.212 g/mole
Smiles notation (if other than submission substance): C(OCCC(C)C)(CC)=O
InChl (if other than submission substance):
1S/C8H16O2/c148(9)10657(2)3/h7H,46H2,13H3
Substance type: Organic
Physical state: Liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
Source: No data
Age at study initiation: No data
Weight at study initiation: 1.5 - 2.5kg
Weight at study initiation: No data
Fasting period before study: No data
Housing: No data
Diet (e.g. ad libitum): No data
Water (e.g. ad libitum): No data
Acclimation period: No data

ENVIRONMENTAL CONDITIONS
Temperature (°C): No data
Humidity (%):No data
Air changes (per hr): No data
Photoperiod (hrs dark / hrs light): No data

IN-LIFE DATES: From: To: No data

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
physiological saline
Details on oral exposure:
No data available
Doses:
6924 mg/kg bw
No. of animals per sex per dose:
10-35 (per sex not mentioned)
Control animals:
not specified
Details on study design:
Duration of observation period following administration: : 24 hrs' observation
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
6 924 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50 % mortality observed
Mortality:
50 % mortality was observed at 6924 mg/kg bw
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Any other information on results incl. tables

No data available

Applicant's summary and conclusion

Interpretation of results:
other: not classified
Conclusions:
LD50 was considered to be 6924 mg/kg bw when rabbits were treated with 3-Methylbutyl propionate orally.
Executive summary:

In a acute oral toxicity study, rabbits were treated with 3-Methylbutyl propionate in the concentration of 6924 mg/kg bw orally by gavage in physiological saline and observed for 24 hours. 50 % mortality was observed at 6924 mg/kg bw. Therefore, LD50 was considered to be 6924 mg/kg bw when rabbits were treated with 3-Methylbutyl propionate orally.