Registration Dossier
Registration Dossier
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EC number: 203-322-1 | CAS number: 105-68-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from Secondary source
Data source
Referenceopen allclose all
- Reference Type:
- other: Authorized database
- Title:
- Acute oral toxicity of CAS no 105-68-0
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- ChemIDplus A TOXNET DATABASE Lite Browse Advanced, 2017
- Reference Type:
- publication
- Title:
- Monographs on Fragrance Raw Materials – Isoamyl Propionate
- Author:
- D. L. J. Opdyke
- Year:
- 1 979
- Bibliographic source:
- Food and Cosmetics Toxicology, Volume 13, Issue 6, Pages 809-810, 1975.
- Reference Type:
- secondary source
- Title:
- SCIENTIFIC LITERATURE REVIEW OF ALIPHATIC PRIMARY ALCOHOLS, ESTERS AND ACIDS IN FLAVOR USAGE Volume I - VII
- Author:
- Flavor and Extract Manufacturer's Association
- Year:
- 1 985
- Bibliographic source:
- NATIONAL TECHNICAL INFORMATION SERVICE, VoL 1, PB86155926, 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as per mentioned below
- Principles of method if other than guideline:
- The acute oral LD50 value in rabbits for isoamyl propionate in rabbits
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- no
Test material
- Reference substance name:
- Isopentyl propionate
- EC Number:
- 203-322-1
- EC Name:
- Isopentyl propionate
- Cas Number:
- 105-68-0
- Molecular formula:
- C8H16O2
- IUPAC Name:
- 3-methylbutyl propanoate
- Test material form:
- not specified
- Details on test material:
- Name of test material (as cited in study report): Isoamyl propionate
Molecular formula (if other than submission substance): C8H16O2
Molecular weight (if other than submission substance): 144.212 g/mole
Smiles notation (if other than submission substance): C(OCCC(C)C)(CC)=O
InChl (if other than submission substance):
1S/C8H16O2/c148(9)10657(2)3/h7H,46H2,13H3
Substance type: Organic
Physical state: Liquid
Constituent 1
- Specific details on test material used for the study:
- Name of test material (as cited in study report): Isoamyl propionate
Molecular formula (if other than submission substance): C8H16O2
Molecular weight (if other than submission substance): 144.212 g/mole
Smiles notation (if other than submission substance): C(OCCC(C)C)(CC)=O
InChl (if other than submission substance):
1S/C8H16O2/c148(9)10657(2)3/h7H,46H2,13H3
Substance type: Organic
Physical state: Liquid
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
Source: No data
Age at study initiation: No data
Weight at study initiation: 1.5 - 2.5kg
Weight at study initiation: No data
Fasting period before study: No data
Housing: No data
Diet (e.g. ad libitum): No data
Water (e.g. ad libitum): No data
Acclimation period: No data
ENVIRONMENTAL CONDITIONS
Temperature (°C): No data
Humidity (%):No data
Air changes (per hr): No data
Photoperiod (hrs dark / hrs light): No data
IN-LIFE DATES: From: To: No data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- physiological saline
- Details on oral exposure:
- No data available
- Doses:
- 6924 mg/kg bw
- No. of animals per sex per dose:
- 10-35 (per sex not mentioned)
- Control animals:
- not specified
- Details on study design:
- Duration of observation period following administration: : 24 hrs' observation
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 6 924 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50 % mortality observed
- Mortality:
- 50 % mortality was observed at 6924 mg/kg bw
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Any other information on results incl. tables
No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Conclusions:
- LD50 was considered to be 6924 mg/kg bw when rabbits were treated with 3-Methylbutyl propionate orally.
- Executive summary:
In a acute oral toxicity study, rabbits were treated with 3-Methylbutyl propionate in the concentration of 6924 mg/kg bw orally by gavage in physiological saline and observed for 24 hours. 50 % mortality was observed at 6924 mg/kg bw. Therefore, LD50 was considered to be 6924 mg/kg bw when rabbits were treated with 3-Methylbutyl propionate orally.
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