3-(2-chloroethyl)-6,7,8,9-tetra-hydro-2-methyl-4H-pyrido[1,2-a] pyrimidin-4-one monohydrochloride

Hydrolysis

Administrative data

Endpoint:

hydrolysis

Type of information:

experimental study

Adequacy of study:

key study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1997

Report date:

1997

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other:

Test material

Test material information

Constituent 1

Test material form:

not specified

Radiolabelling:

no

Results and discussion

Dissipation DT50 of parent compound

Dissipation DT50 of parent compound 1

Key result

pH:

5

Temp.:

25 °C

Hydrolysis rate constant:

0.053 h-1

DT50:

13.08 h

Type:

(pseudo-)first order (= half-life)

Remarks on result:

other:

Dissipation DT50 of parent compound 2

Key result

pH:

7

Temp.:

25 °C

Hydrolysis rate constant:

0.062 h-1

DT50:

11.18 h

Type:

(pseudo-)first order (= half-life)

Remarks on result:

other:

Dissipation DT50 of parent compound 3

Key result

pH:

9

Temp.:

25 °C

Hydrolysis rate constant:

0.06 h-1

DT50:

11.55 h

Type:

(pseudo-)first order (= half-life)

Remarks on result:

other:

Applicant's summary and conclusion

Validity criteria fulfilled:

yes