Registration Dossier
Registration Dossier
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EC number: 204-896-6 | CAS number: 128-58-5
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
- Principles of method if other than guideline:
- Method: other: BASF-Test
- GLP compliance:
- no
- Test type:
- other: BASF Method
- Limit test:
- yes
Test material
- Reference substance name:
- 16,17-dimethoxyviolanthrene-5,10-dione
- EC Number:
- 204-896-6
- EC Name:
- 16,17-dimethoxyviolanthrene-5,10-dione
- Cas Number:
- 128-58-5
- Molecular formula:
- C36H20O4
- IUPAC Name:
- 16,17-dimethoxyviolanthrene-5,10-dione
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
- Remarks:
- saturated with test item at 20°C
- Details on inhalation exposure:
- Inhalation by means of vapuor saturated at 20°C for 4 hours. To achieve saturation, air was fed through an approx. 5 cm deep layer of the product.
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- saturation concentration
- No. of animals per sex per dose:
- 12 rats
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily observation
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, necropsy - Statistics:
- NA
Results and discussion
- Preliminary study:
- NA
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 0.32 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: technically highest concentration in air
- Mortality:
- no deaths
- Clinical signs:
- other: no effects
- Body weight:
- no data
- Gross pathology:
- no effects
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The 4-h LC50 in rat was determined to be > 0.32 mg/L air which was the technically possibly highest concentration.
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