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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from handbooks and RTECS

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Eye irritation of 2-aminonaphthalene-1,5-disulfonic acid
Author:
Richard J Lewis, Sr
Year:
2012
Bibliographic source:
SAX's Dangerous properties of industrial material, 12th edition, 2012
Reference Type:
secondary source
Title:
RTECS - QJ6135000, review date – January, 1997
Author:
RTECS®
Year:
1997
Bibliographic source:
RTECS - QJ6135000, RTECS®, review date – January, 1997

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To assess the eye irritation potential of 2-aminonaphthalene-1,5-disulfonic acid in rabbits
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-aminonaphthalene-1,5-disulphonic acid
EC Number:
204-201-6
EC Name:
2-aminonaphthalene-1,5-disulphonic acid
Cas Number:
117-62-4
Molecular formula:
C10H9NO6S2
IUPAC Name:
2-aminonaphthalene-1,5-disulfonic acid
Test material form:
solid
Details on test material:
- Name of test material :2-aminonaphthalene-1,5-disulfonic acid
- Molecular formula : C10H9NO6S2
- Molecular weight : 303.314 g/mol
- Smiles notation : c12c(c(ccc2)S(O)(=O)=O)ccc(c1S(O)(=O)=O)N
- InChl : 1S/C10H9NO6S2/c11-8-5-4-6-7(10(8)19(15,16)17)2-1-3-9(6)18(12,13)14/h1-5H,11H2,(H,12,13,14)(H,15,16,17)
- Substance type:Organic
- Physical state:Solid
Specific details on test material used for the study:
- Name of test material: 2-aminonaphthalene-1,5-disulfonic acid
- Molecular formula: C10H9NO6S2
- Molecular weight: 303.314 g/mol
- Smiles notation: c12c(c(ccc2)S(O)(=O)=O)ccc(c1S(O)(=O)=O)N
- InChl: 1S/C10H9NO6S2/c11-8-5-4-6-7(10(8)19(15,16)17)2-1-3-9(6)18(12,13)14/h1-5H,11H2,(H,12,13,14)(H,15,16,17)
- Substance type: Organic
- Physical state: Solid

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
no data available

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
20mg
Duration of treatment / exposure:
24 hours
Observation period (in vivo):
24 hours
Duration of post- treatment incubation (in vitro):
no data available
Number of animals or in vitro replicates:
no data available
Details on study design:
no data available

Results and discussion

In vitro

Other effects / acceptance of results:
no data available

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24 h
Reversibility:
not specified
Remarks on result:
probability of moderate irritation
Irritant / corrosive response data:
Moderate irritation observed

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritating to eyes) based on GHS criteria
Conclusions:
20 mg of 2-aminonaphthalene-1,5-disulfonic acid caused moderate irritation to the rabbit eyes after 24 hours.
Hence, 2-aminonaphthalene-1,5-disulfonic acid can be considered moderately irritating rabbit eyes.

Executive summary:

The eye irritation potential of 2-aminonaphthalene-1,5-disulfonic acid was assessed in rabbits.20 mg of 2-aminonaphthalene-1,5-disulfonic acid was instilled into the eyes of rabbits. The rabbits were observed for signs of ocular lesions till 24 hours.

20 mg of 2-aminonaphthalene-1,5-disulfonic acid caused moderate irritation to the rabbit eyes after 24 hours.

Hence, 2-aminonaphthalene-1,5-disulfonic acid can be considered moderately irritating rabbit eyes.

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