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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from secondary source

Data source

Referenceopen allclose all

Reference Type:
other: Authoritative database
Title:
Acute oral toxicity on rats for CAS no:90-51-7
Author:
GESTIS Substance Database
Year:
2017
Bibliographic source:
GESTIS Substance Database, IFA Institute for Occupational safety and health of the German social Accident Insurance.
Reference Type:
publication
Title:
Toxicity and ecotoxicity of sulfonic acids: Structure-activity relationship.
Author:
Greim H. J. Ahlers R. Bias B. Broecker H. Hollander H.-P. Gelbke H.-J. Klimisch I. Mangelsdorf A. Paetz N Schön G. Stropp R. Vogel C. Weber K. Ziegler-Skylakakis E. Bayer
Year:
1994
Bibliographic source:
Chemosphere 28(12):2203-2236, June 1994
Reference Type:
review article or handbook
Title:
Toxicological evaluations of 6-amino-4-hydroxynaphthalene-2-sulphonic acid
Author:
BG Chemie
Year:
2000
Bibliographic source:
BG Chemie "Toxikologische Bewertungen" 15. No. 227, Ergänzungslieferung, 06/2000

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Rats were administered orally by 6-amino-4-hydroxynaphthalene-2-sulphonic acid followed by 14 days observation period to study the toxic effects.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
6-amino-4-hydroxynaphthalene-2-sulphonic acid
EC Number:
202-000-8
EC Name:
6-amino-4-hydroxynaphthalene-2-sulphonic acid
Cas Number:
90-51-7
Molecular formula:
C10H9NO4S
IUPAC Name:
6-amino-4-hydroxynaphthalene-2-sulfonic acid
Test material form:
solid
Details on test material:
- Name of test material (as cited in study report): 6-amino-4-hydroxynaphthalene-2-sulphonic acid
- Molecular formula : C10H9NO4S
- Molecular weight : 239.26g/mol
- Substance type: Organic
- Physical state: solid
- Purity: No data
- Impurities (identity and concentrations):No data
Specific details on test material used for the study:
- Name of test material (as cited in study report): 6-amino-4-hydroxynaphthalene-2-sulphonic acid
- Molecular formula : C10H9NO4S
- Molecular weight : 239.26g/mol
- Substance type: Organic
- Physical state: solid
- Purity: No data
- Impurities (identity and concentrations):No data

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
water
Details on oral exposure:
No data availableVEHICLE:water
- Concentration in vehicle: No data available
- Amount of vehicle (if gavage):No data available
- Justification for choice of vehicle:soluble in water
- Lot/batch no. (if required): No data available
- Purity: No data available

MAXIMUM DOSE VOLUME APPLIED: No data available

DOSAGE PREPARATION (if unusual):Test material dry and ground formulated in water

CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose:No data available
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
10
Control animals:
not specified
Details on study design:
Duration of observation period following administration: 14 days- Duration of observation period following administration: 14 days
- Frequency of observations and weighing:No data available
- Necropsy of survivors performed: No data available
- Other examinations performed: clinical signs were observed
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality was observed
Mortality:
No mortality was observed.
Clinical signs:
No clinical signs were observed.
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: Not Classified
Conclusions:
In rats, the lethal dose for oral administration of 6-amino-4-hydroxynaphthalene-2-sulphonic acid was considered to be > 5000 mg/kg bw.
Executive summary:

In Acute oral toxicity test, Ten male Wistar-rats were administered orally with the dose of 5000 mg/kg bw of 6-amino-4-hydroxynaphthalene-2-sulphonic acid (gamma acid), dry and ground, formulated in water and all the animals were observed for p 14 days, all animals were survived on single oral administration of >5000 mg/kg bw. No clinical signs were observed.Hence the lethal dose concentration (LD50) was considered to be >5000mg/kg bw. When rats were treated with 6-amino-4-hydroxynaphthalene-2-sulphonic acid (90 -51 -7) orally.