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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

Short-term toxicity to fish: 96 hr EC50 >0.000075 mg/l (measured) (highest concentration tested) (OECD 203), read-across from an analogous/structurally related substance, dodecamethylpentasiloxane (L5, CAS 141-63-9).

Key value for chemical safety assessment

Additional information

There are no reliable short-term fish toxicity data available for tetradecamethylhexasiloxane (L6, CAS 107-52-8), therefore good quality data from appropriate structural analogues, dodecamethylpentasiloxane (L5, CAS 141-63-9) and decamethyltetrasiloxane (L4, CAS 141 -62 -8), have been read across.

 

A 96-h E(L)C50 value of >0.000075 mg/l and NOEC of ≥0.000075 mg/l (measured) (highest concentration tested) have been determined for the effects of dodecamethylpentasiloxane (L5, CAS 141-63-9) on mortality of Oncorhynchus mykiss. In view of the test media preparation method/exposure regime it is likely that the test organisms were exposed predominantly to the tested substance.

A 96-hour LC50 value of >6.3 μg/l (>0.0063 mg/l) and NOEC of ≥6.3 μg/L (>= 0.0063 mg/l) (mean measured; highest concentration tested) have been determined for the effects of decamethyltetrasiloxane (L4, CAS 141-62 -8) on mortality of Oncorhynchus mykiss based on mean measured exposure concentrations. In view of the use of flow-through test conditions it is likely that the test organisms were exposed primarily to the parent substance.

 

Refer to IUCLID Section 6 endpoint summary (CSR Section 7.0) for further information on the approach to chemical safety assessment for this registration substance, and justification for read-across used.