Registration Dossier

Administrative data

First-aid measures

4.1. Description of first aid measures
Immediately remove contaminated clothing. If the patient is likely to become unconscious, place and transport in stable sideways position (recovery position). First aid personnel should pay attention to their own safety.

If inhaled:
Keep patient calm, remove to fresh air, seek medical attention. Immediately administer a corticosteroid from a controlled/metered dose inhaler.

On skin contact:
Immediately wash thoroughly with plenty of water, apply sterile dressings, consult a skin specialist.

On contact with eyes:
Immediately wash affected eyes for at least 15 minutes under running water with eyelids held open, consult an eye specialist.

On ingestion:
Rinse mouth immediately with water. Immediate medical attention required.


4.2. Most important symptoms and effects, both acute and delayed
Symptoms: The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11., Further symptoms are possible


4.3. Indication of any immediate medical attention and special treatment needed
Treatment: Treat according to symptoms (decontamination, vital functions), no known specific antidote. Pulmonary odema prophylaxis. Medical monitoring for at least 24 hours.

Fire-fighting measures

5.1. Extinguishing media
Suitable extinguishing media:
water spray, dry powder, foam, carbon dioxide

5.2. Special hazards arising from the substance or mixture
nitrogen oxides, carbon oxides
The substances/groups of substances mentioned can be released in case of fire. Under certain conditions in case of fire other hazardous combustion products may be generated.

5.3. Advice for fire-fighters
Special protective equipment:
Wear self-contained breathing apparatus and chemical-protective clothing.

Further information:
Collect contaminated extinguishing water separately, do not allow to reach sewage or effluent systems.

Accidental release measures

6.1. Personal precautions, protective equipment and emergency procedures
Breathing protection required. Avoid contact with the skin, eyes and clothing.

6.2. Environmental precautions
Do not empty into drains.

6.3. Methods and material for containment and cleaning up
For large amounts: Pump off product.
For residues: Pick up with suitable absorbent material (e.g. sand, sawdust, general-purpose binder, kieselguhr).
Cleaning operations should be carried out only while wearing breathing apparatus. Clean contaminated floors and objects thoroughly with water and detergents, observing environmental regulations. Collect waste in suitable containers, which can be labeled and sealed. Incinerate or take to a special waste disposal site in accordance with local authority regulations.

6.4. Reference to other sections
Information regarding exposure controls/personal protection and disposal considerations can be found in section 8 and 13.

Handling and storage

7.1. Precautions for safe handling
Ensure thorough ventilation of stores and work areas. Refill and handle product only in closed system. Avoid aerosol formation. Handle in accordance with good industrial hygiene and safety practice. When using do not eat, drink or smoke. Hands and/or face should be washed before breaks and at the end of the shift.

Protection against fire and explosion:
Prevent electrostatic charge - sources of ignition should be kept well clear - fire extinguishers should be kept handy.

7.2. Conditions for safe storage, including any incompatibilities
Segregate from acids and acid forming substances.

Suitable materials for containers: Carbon steel (Iron), Stainless steel 1.4401, Stainless steel 1.4301 (V2), glass
Further information on storage conditions: Keep container tightly closed in a cool, well-ventilated place.

Storage class according to TRGS 510 (originally VCI, Germany): (6.1C) Combustible substances of acute toxicity, category 3 / hazardous substances that are toxic or produce chronic effects

Storage stability:
Storage temperature: 25 °C
Storage duration: 24 Months
From the data on storage duration in this safety data sheet no agreed statement regarding the warrantee of application properties can be deduced.

7.3. Specific end use(s)
For the relevant identified use(s) listed in Section 1 the advice mentioned in this section 7 is to be observed.

Transport information

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Marine transport (IMDG)

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Exposure controls / personal protection

8.1. Control parameters

Components with occupational exposure limits

The surveillance of the workplace by exposure measurements may be necessary, in order to proof the efficiency of safety measures, for example ventilation or the need of respiratory protection. Since this requires a specific competency, only accredited laboratories should be contracted. Regarding suitable methods to assess inhalative exposure the European Standards EN 482, 689 and 14042 are to be considered. In addition the TRGS 402 has to be observed in Germany.

110-85-0: piperazine
TWA value 0,1 mg/m3 (OEL (EU))
indicative
STEL value 0,3 mg/m3 (OEL (EU))
indicative
OEL 0,1 mg/m3 (TRGS 900 (DE)), Vapor and aerosol
Ceiling limit value/factor: 1
corrosive, toxic
Short Term Exposure Classification: (TRGS 900 (DE)), Vapor and aerosol
Category I: Substances for which the localized effect has an assigned exposure limit or for substances with a sensitizing effect in respiratory passages
141-43-5: 2-aminoethanol
STEL value 7,6 mg/m3 ; 3 ppm (OEL (EU))
indicative
TWA value 2,5 mg/m3 ; 1 ppm (OEL (EU))
indicative
Skin Designation (OEL (EU))
The substance can be absorbed through the skin.
Short Term Exposure Classification: (TRGS 900 (DE)), Vapor and aerosol
Category I: Substances for which the localized effect has an assigned exposure limit or for substances with a sensitizing effect in respiratory passages
OEL 0,5 mg/m3 ; 0,2 ppm (TRGS 900 (DE)), Vapor and aerosol
Ceiling limit value/factor: 1
Sum of vapors and aerosols.
Skin Designation (TRGS 900 (DE)), Vapor and aerosol
The substance can be absorbed through the skin.

PNEC
freshwater: 0,0005 mg/l

marine water: 0,00005 mg/l

intermittent release: 0,005 mg/l

STP: 0,29 mg/l

sediment (freshwater):
No PNEC value available.

sediment (marine water):
No PNEC value available.

soil:
No PNEC value available.

oral (secondary poisoning):
No PNEC value available.


DNEL
No DNELs have been derived.

No DNELs have been derived.


8.2. Exposure controls
Personal protective equipment
Respiratory protection:
Self-contained breathing apparatus.

Hand protection:
Chemical resistant protective gloves (EN 374)
Suitable materials also with prolonged, direct contact (Recommended: Protective index 6, corresponding > 480 minutes of permeation time according to EN 374):
butyl rubber (butyl) - 0.7 mm coating thickness
fluoroelastomer (FKM) - 0.7 mm coating thickness
Manufacturer's directions for use should be observed because of great diversity of types.

Supplementary note: The specifications are based on tests, literature data and information of glove manufacturers or are derived from similar substances by analogy. Due to many conditions (e.g. temperature) it must be considered, that the practical usage of a chemical-protective glove in practice may be much shorter than the permeation time determined through testing.

Eye protection:
Tightly fitting safety goggles (cage goggles) (e.g. EN 166) and face shield.

Body protection:
Body protection must be chosen depending on activity and possible exposure, e.g. apron, protecting boots, chemical-protection suit (according to EN 14605 in case of splashes or EN ISO 13982 in case of dust).

General safety and hygiene measures
The substance was registered as a transported isolated intermediate. The manufacturer/importer has received the confirmation by the user that the substance is used under strictly controlled conditions in accordance with art. 18 of the REACH regulation (EC) No 1907/2006. Avoid contact with the skin, eyes and clothing. Do not breathe vapour/spray. Females of childbearing age should not come into contact with the product. Remove contaminated clothing immediately and dispose of safely. When using, do not eat, drink or smoke. Handle in accordance with good industrial hygiene and safety practice.

Stability and reactivity

10.1. Reactivity
No hazardous reactions if stored and handled as prescribed/indicated.

Formation of flammable gases: Remarks: Forms no flammable gases in the presence of water.


10.2. Chemical stability
The product is stable if stored and handled as prescribed/indicated.

10.3. Possibility of hazardous reactions
Strong exothermic reaction with acids.


10.4. Conditions to avoid
Avoid all sources of ignition: heat, sparks, open flame. Avoid extreme heat.

10.5. Incompatible materials

Substances to avoid:
acids, acid forming substances, nitrosating agents

10.6. Hazardous decomposition products

Possible decomposition products:
nitrogen oxides, nitrous gases, carbon oxides

Disposal considerations

13.1. Waste treatment methods

Incinerate in suitable incineration plant, observing local authority regulations.


Contaminated packaging:
Contaminated packaging should be emptied as far as possible; then it can be passed on for recycling after being thoroughly cleaned.