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EC number: 216-372-4 | CAS number: 1569-01-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: non-GLP study equivalent to OECD guideline 402
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1-propoxypropan-2-ol
- EC Number:
- 216-372-4
- EC Name:
- 1-propoxypropan-2-ol
- Cas Number:
- 1569-01-3
- Molecular formula:
- C6H14O2
- IUPAC Name:
- 1-propoxypropan-2-ol
- Details on test material:
- Name of test material (as cited in study report): PROPASOL Solvent P
- Physical state: clear, non-viscous liquid
- Lot/batch No.: #3251; S-066890
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.0 - 3.0 kg
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: clipped intact skin of the trunk
- Type of wrap if used: Test material was retained under impervious sheeting. Vetrap Bandaging Tape was wrapped over the impervious sheeting.
REMOVAL OF TEST SUBSTANCE
After the contact period (24 hours) excess fluid was removed to diminish ingestion.
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2.0, 4.0, 8.0 ml/kg
- Concentration (if solution): pure (liquid) substance
- Constant volume or concentration used: doses are varied by adjusting the volume of the test material - Duration of exposure:
- 24 hours
- Doses:
- 2.0, 4.0, 8.0 ml/kg
The relative density of Propasol Solvent P is 0.88 g/ml. - No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: animals weights were recorded at 0 days (before dose), 7 days and 14 days (just prior to sacrifice)
- Necropsy of survivors performed: at death or sacrifice each animal was subjected to gross pathologic evaluation - Statistics:
- LD50's and the estimated LD50 slopes are calculated by the moving average method and are based on a 14-day observation period.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 4.29 mL/kg bw
- 95% CL:
- 2.9 - 6.34
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 4.92 mL/kg bw
- 95% CL:
- 3.58 - 6.78
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3 775 mg/kg bw
- 95% CL:
- 2 552 - 5 579
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 4 330 mg/kg bw
- 95% CL:
- 3 150 - 5 966
- Mortality:
- 8.0 ml/kg (males): 5/5
4.0 ml/kg (males): 2/5
2.0 ml/kg (males): 0/5
8.0 ml/kg (females): 5/5
4.0 ml/kg (females): 1/5
2.0 ml/kg (females): 0/5 - Clinical signs:
- other: 8.0 ml/kg (males): erythema, edema, necrosis at death; ecchymosis on 2 at death; comatose appearance within 15 min; dilated pupils in 2 at death; death of 4 at 2.5-3.5 hours 4.0 ml/kg (males): erythema, edema at 1 day; ecchymosis on 2 at 1 to 7 days; necr
- Gross pathology:
- 8.0 ml/kg (males): tracheas red
4.0 ml/kg (males): in victims: lungs mottled, dark red; tracheas red; in survivors: nothing remarkable
2.0 ml/kg (males): nothing remarkable
8.0 ml/kg (females): lungs dark red; trachea of 1 red
4.0 ml/kg (females): in victim: lungs and trachea red; in survivors: nothing remarkable
2.0 ml/kg (females): lungs of 2 mottled light and dark pink
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- PROPASOL Solvent P was moderately toxic following single dermal application. According to EU criteria no classification for acute dermal toxicity is required based on the LD50 > 2000 mg/l.
- Executive summary:
Three groups of 5 male and 5 female New Zealand White rabbits, weighing between 2.0 and 3.0 kg, were subjected to 24 hours of contact with 8.0, 4.0 or 2.0 ml/kg of PROPASOL Solvent P which was retained under impervious sheeting on the clipped, intact skin of the trunk. As necessary for larger doses, gauze was wrapped around the trunk over the sample to prevent leakage. Vetrap Bandaging Tape was wrapped over the impervious sheeting and the animal was returend to its cage for the contact period. Doses were varied by adjusting the volume of the test material. After the contact period, excess fluid is removed to diminish ingestion. Observations for skin reaction were made at one hour, 7 days and 14 days after the contact period.
The LD50 for male rabbits was 4.29 ml/kg. The LD50 for females was 4.92 ml/kg. Local dermal effects included erythema, edema, ecchymosis, necrosis, desquamation, fissuring, ulceration, scabs and alopecia. A rapid comatose appearance, followed by dilated pupils, unsteady gait, sluggishness and prostration were among the signs of toxicity observed. Time to death ranged from one hour to 2 days. Survivors recovered at one to 2 days. Gross pathologic findings included red lungs and red tracheas.
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