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EC number: 216-372-4 | CAS number: 1569-01-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
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- Nanomaterial pour density
- Nanomaterial photocatalytic activity
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- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
No ADME studies are available for propylene glycol n-propyl ether (PnP) as such. Therefore, the toxicokinetics assessment is based on the available data from repeated dose toxicity studies and on data for the structurally related propylene glycol n-butyl ether (PnB).
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 30
- Absorption rate - inhalation (%):
- 100
Additional information
Both oral and inhalation absorption rates for PnP were set at 100%. For detailed information, refer to read-across justification document for P-series glycol ethers. Dermal absorption rate was based on PM and set at 30%.
No ADME studies are available for propylene glycol n-propyl ether (PnP) as such. The assessment is based on available data from repeated dose toxicity studies and on structurally related propylene glycol ethers. PnP is expected to be metabolised predominantly in the liver to propylene glycol and the propyl alcohol. These metabolites may be further metabolised to CO2 and water, with the latter ultimately being excreted in expired air. Alternatively, PnP (or the intermediate metabolite) may be conjugated in the liver with glucuronide, sulfate, or glutathione for excretion, predominantly in the urine.
Discussion on bioaccumulation potential result:
Metabolism of PnP takes place predominantly in the liver where mixed function oxidase cleaves the ether linkage, yielding propylene glycol and the alcohol. These two products may be further metabolised to CO2 and water, with the latter ultimately being excreted in expired air, or the parent or the metabolites can be conjugated in the liver with glucuronide, sulfate, or glutathione. Excretion takes place predominantly in the urine.
PnP is rapidly absorbed and distributed throughout the body when introduced by inhalation or oral exposure. Dermal absorption is somewhat slower but subsequent distribution also is rapid.
Overall, no bioaccumulation potential is expected for PnP and other glycol ethers.
As a class, the propylene glycol ethers are rapidly absorbed and distributed throughout the body when introduced by inhalation or oral exposure. Metabolism studies (by oral exposure) conducted with several PGEs support this conclusion. While not tested directly, absorption by inhalation exposure also would be expected to be rapid for PGEs aerosols that are in the respirable range. Rapid absorption, distribution, and elimination occurred within 48 hours for several PGEs. Most excretion for PGEs is via the urine and expired air. A small portion is excreted in the feces.
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