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Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1992
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Qualifier:
according to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
GLP compliance:
no
Analytical monitoring:
yes
Remarks:
Measurement of TOC content
Test organisms (species):
Danio rerio (previous name: Brachydanio rerio)
Test type:
static
Water media type:
freshwater
Limit test:
yes
Total exposure duration:
96 h
Test temperature:
23.0°C
pH:
8.1 - 8.2
Dissolved oxygen:
O2 (%): 90 - 97
Nominal and measured concentrations:
398 mg/L (nominal) corresponding to 120.6 mg a.i./L
(150 mg/L TOC)
Reference substance (positive control):
no
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
55 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Remarks on result:
other: geometric mean value of LC0 and LC100
Duration:
96 h
Dose descriptor:
LC0
Effect conc.:
30 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
LC100
Effect conc.:
100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Validity criteria fulfilled:
not specified
Conclusions:
Under the study conditions, the nominal 96 h LC0 and 100 were determined to be 30 and 100 mg/L, respectively. Based on the LC0 and LC100, the LC50 was calculated as geometric mean value: 55 mg/L (nominal).
Executive summary:

A study was conducted to determine the toxicity of the test substance (purity 30.3%) according to OECD Guideline 203. Zebra fish (Danio rerio) were exposed for 96 h to nominal concentrations of 0, 30, 100 and 300 mg/L. Mortality was assessed daily. No analytical determination of test substance concentration was performed. Under the study conditions, the nominal 96 h LC0 and 100 were determined to be 30 and 100 mg/L, respectively (Inauen, 1992). Based on the LC0 and LC100, the LC50 was calculated as geometric mean value: 55 mg/L (nominal).

Description of key information

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
55 mg/L

Additional information

A study was conducted to determine the toxicity of the test substance (purity 30.3%) according to OECD Guideline 203. Zebra fish (Danio rerio) were exposed for 96 h to nominal concentrations of 0, 30, 100 and 300 mg/L. Mortality was assessed daily. No analytical determination of test substance concentration was performed. Under the study conditions, the nominal 96 h LC0 and 100 were determined to be 30 and 100 mg/L, respectively (Inauen, 1992). Based on the LC0 and LC100, the LC50 was calculated as geometric mean value: 55 mg/L (nominal).