Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Endpoint summary
Administrative data
Description of key information
Guideline conform skin and eye irritation studies in rabbits were performed under GLP conditions. The test substance was not irritating to rabbit skin and showed slight, reversible eye irritation. The substance is therefore not classified for skin- or eye irritation.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
The test item was not irritating to rabbit skin in any of the test animals at any time point. Slight eye irritation (mean 24, 48, 72 h 0.66 in 3 animals for conuctival redness and 0.33 for conjunctival chemosis) was observed in the rabbit eye irritation test.
Effects on eye irritation: slightly irritating
Justification for classification or non-classification
The test item did not show any skin irritating effects in a guideline study in rabbits. The irritation scores observed in the eye irritation study in rabbits accordign to current guidelines do not warrant a clssification as eye irritant. From the existing studies no conclusion on possible respriatory irritation can be drawn, but the low irritation potential does not indicate a concern for respiratory irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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