Registration Dossier

Toxicological information

Neurotoxicity

Currently viewing:

Administrative data

Description of key information

OECD 422; rat; NOAEL (neurotoxicity) = 800 mg/kg (highest dose level tested). Reliability = 1

Key value for chemical safety assessment

Effect on neurotoxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
NOAEL
800 mg/kg bw/day
Study duration:
subacute
Species:
rat

Effect on neurotoxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Effect on neurotoxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

A combined repeated dose feeding toxicity study with the reproduction/developmental toxicity screening test according to OECD Guideline 422 was conducted in rats at dose levels of 0, 10, 50, 200, or 800 mg/kg/day. An abbreviated neurobehavioral evaluation consisting of a functional observational battery and motor activity was conducted in P1 rats once during pretest and again near the end of the premating period. There were no test substance-related effects on any neurobehavioral parameters evaluated in male or female rats administered up to 800 mg/kg/day of the test substance.

Justification for classification or non-classification