Registration Dossier
Registration Dossier
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EC number: 807-008-0 | CAS number: 1173693-36-1
Neurotoxicity
Administrative data
Description of key information
OECD 422. NOAEL (neurotoxicity) = 12050 ppm (highest dose level tested) Reliability = 1
Key value for chemical safety assessment
Effect on neurotoxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- GLP, guideline study
Effect on neurotoxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Effect on neurotoxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
A combined repeated dose feeding toxicity study with the reproduction/developmental toxicity screening test was conducted in rats at dose levels of 0, 120, 715, 4280, or 12050 ppm. An abbreviated neurobehavioral evaluation consisting of a functional observational battery and motor activity was conducted in P1 rats once during pretest and again near the end of the premating period. There were no test substance-related effects on any neurobehavioral parameters evaluated in male or female rats administered up to 12050 ppm of the test substance.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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