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Toxicological information

Neurotoxicity

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Administrative data

Description of key information

OECD 422. NOAEL (neurotoxicity) = 12050 ppm (highest dose level tested)  Reliability = 1

Key value for chemical safety assessment

Effect on neurotoxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Study duration:
subchronic
Species:
rat
Quality of whole database:
GLP, guideline study

Effect on neurotoxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Effect on neurotoxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

A combined repeated dose feeding toxicity study with the reproduction/developmental toxicity screening test was conducted in rats at dose levels of 0, 120, 715, 4280, or 12050 ppm. An abbreviated neurobehavioral evaluation consisting of a functional observational battery and motor activity was conducted in P1 rats once during pretest and again near the end of the premating period. There were no test substance-related effects on any neurobehavioral parameters evaluated in male or female rats administered up to 12050 ppm of the test substance.

Justification for classification or non-classification