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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information


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Administrative data

Description of key information

OECD 422. NOAEL (neurotoxicity) = 12050 ppm (highest dose level tested)  Reliability = 1

Key value for chemical safety assessment

Effect on neurotoxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Study duration:
Quality of whole database:
GLP, guideline study

Effect on neurotoxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Effect on neurotoxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

A combined repeated dose feeding toxicity study with the reproduction/developmental toxicity screening test was conducted in rats at dose levels of 0, 120, 715, 4280, or 12050 ppm. An abbreviated neurobehavioral evaluation consisting of a functional observational battery and motor activity was conducted in P1 rats once during pretest and again near the end of the premating period. There were no test substance-related effects on any neurobehavioral parameters evaluated in male or female rats administered up to 12050 ppm of the test substance.

Justification for classification or non-classification