Reaction product of a ((2S)-2, 6-diaminohexanoic acid hydrochloride salt, phosphonic acid and methanal) with a 1,2-disubstituted alkane and sodium hydroxide.

Adsorption / desorption

Link to relevant study record(s)

Reference

Endpoint:

adsorption / desorption: screening

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))

Qualifier:

according to guideline

Guideline:

EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))

GLP compliance:

yes (incl. QA statement)

Type of method:

HPLC estimation method

Radiolabelling:

no

Test temperature:

30 degrees centigrade

Details on study design: HPLC method:

HPLC System: Agilent Technologies 1100 Series
Column: XSelect HSS Cyano 5 μm (150 x 4.6 mm id)
Column temperature: 30ºC
Mobile phase: Methanol: Purified water (55:45 v/v)
pH of mobile phase: 6.2
Flow-rate: 1.0 mL/min
Injection volume: 10 μL
UV detector wavelength: 210 nm
Substance for dead time: Formamide (654 mg/L in mobile phase)
Dead time: 1.892 minutes

Key result

Type:

Koc

Value:

< 17.8

Temp.:

30 °C

Key result

Type:

log Koc

Value:

< 1.25

Temp.:

30 °C

Details on results (HPLC method):

Reference substance retention times are detailed in any other information section below

Partition coefficient (HPLC method)

Dead time to / min:
No.	Reference substance	Retention time (min)	log k value	log Koc value
1	Acetanilide	2.599	-0.428	1.25
2	Phenol	2.473	-0.513	1.32
3	Atrazine	3.596	-4.56 x 10^-2	1.81
4	Isoproturon	3.841	1.28 x 10^-2	1.86
5	Aniline	2.729	-0.354	2.07
6	Triadimenol	5.118	0.232	2.40
7	Linuron	5.255	0.250	2.59
8	Naphthalene	4.548	0.147	2.75
9	Endosulfan-Diol	6.466	0.383	3.02
10	Fenthion	7.783	0.493	3.31
11	a-Endosulfan	10.959	0.680	4.09
12	Diclofop-Methyl	11.824	0.720	4.20
13	Phenanthrene	8.454	0.540	4.09
14	DDT	23.259	1.05	5.63
TS1	SPE1415	1.411	<-0.428	<1.25

Validity criteria fulfilled:

yes

Conclusions:

The adsorption coefficient (Koc) of the substance is less than 17.8, log10Koc less than 1.25. These values indicate that the test item will have a very high mobility in the environment.

Executive summary:

The adsorption coefficient (K_oc) of SPE1415 was determined according to OECD Guideline for the Testing of Chemicals No. 121 “Estimation of the Adsorption Coefficient (K_oc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC)”, adopted 22 January 2001. The test method was designed to be compatible with Method C19 “Estimation of the Adsorption Coefficient (K_oc) on Soil and on Sewage Sludge using high Performance Liquid Chromatography (HPLC)”

The K_ocwas estimated to be <1.25 (highest standard) and the adsorption coefficient was <17.78. These values demonstrate that SPE1415 will have a very high mobility in the environment.

Reference substances (and respective log K_ocvalues) were: Acetanilide (1.25), Phenol (1.32), Atrazine (1.81), Isoproturon (1.86), Aniline (2.07), Triadimenol (2.40), Linuron (2.59), Naphthalene (2.75), Endosulfan-Diol (3.02), Fenthion (3.31),a-Endosulfan (4.09), Diclofop-Methyl (4.20), Penanthrene (4.09) and DDT (5.63).

The calibration showed a correlation of 0.903.

Description of key information

A reliable (Klimisch 1) study is available for the test item. The study was conducted according to GLP and following internationally accepted test guidelines.

The adsorption coefficient (Koc) of the substance is less than 17.8, log10Koc less than 1.25. These values indicate that the test item will have a very high mobility in the environment

Key value for chemical safety assessment

Koc at 20 °C:

17.8

Additional information

[LogKoc: 1.25]