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EC number: 701-140-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Skin: not irritating, not corrosive
Eye: irritating, not corrosive
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation/corrosion
The irritation/corrosion property was tested on the Similar substances 01 and the Similar substance 02, according to the OECD404 and EU B.4, in GLP.
Under the conditions of the experiment, the tested substances were found to not cause corrosion or irritating effects.
Based on the read-across principle, the results can be considered for the skin irritation assessment of the registered substance.
Justification for read-across is detailed in the report attached to the IUCLID section 13.
Due to the results described above, the registered substance is considered non irritant for the skin.
Eye irritation/corrosion
The eye irritation/corrosion property was tested on the Similar substance 01, according to the OECD 405 and EU B.5, in GLP.
Under the conditions of this experiment, the substance was found to cause a primary irritation score or f 4.58, when applied to the conjunctival sac of the rabbit eye. An irritant effect was observed, but fully reversible after 14 days.
According to EEC Council Directive, 83/467/EEC, July 1983 and 67/548/EEC, May 1987, Brussels, Belgium, the mean value of the scores was calculated, indicating that the test article had to be classified as irritating to the eyes.
It should be noted that no rinsing of the eyes has been performed before the evaluation, therefore to confirm the outcome an additional study in read across on the Similar substance 02 was evaluated.
The Similar substance 02 is classified as irritant.
Based on the read-across principle, the results can be considered for the eye irritation assessment of the registered substance.
Justification for read-across is detailed in the report attached to the IUCLID section 13.
Due to the results described above, the registered substance is considered irritant for the eyes.
Justification for classification or non-classification
Skin irritation/corrosion
Substances that have the potential to induce reversible skin irritation are classified in Category 2 (irritating to skin).
According to the CLP Regulation 1272/2008, the substance can be classify as a single irritant category (Category 2) according to the criteria, section 3.2, table 3.2.2.
If, when applied to the skin of an animal, the substance produces:
(1) Mean value of ≥ 2,3 - ≤ 4,0 for erythema/eschar or for oedema in at least 2 of 3 tested animals from grading at 24, 48 and 72 hours after patch removal or, if reactions are delayed, from grades on 3 consecutive days after the onset of skin reactions; or
(2) Inflammation that persists to the end of the observation period normally 14 days in at least 2 animals, particularly taking into account alopecia (limited area), hyperkeratosis, hyperplasia, and scaling; or
(3) In some cases where there is pronounced variability of response among animals, with very definite positive effects related to chemical exposure in a single animal but less than the criteria above. Reversibility of skin lesions is the other decisive factor in evaluating responses in the animal test.
Under the conditions of the experiments, the tested substances (Similar substances 01 and 02) were found to cause a primary irritation score of 0.00 when applied to intact rabbit skin. No corrosive effect had occurred on the skin at any measuring interval.
Local signs (mean between 1 hour to 72 hours) consisted of grade 0.00 erythema and grade 0.00 edema.
Based on the read-across principle, the results can be considered for the skin irritation assessment of the substance.
According to the paragraph 3.2. of the CLP Regulation n. 1272/2008, the substance is not classified as a skin irritant/skin corrosive.
Eye irritation/corrosion
Substances that have the potential to induce reversible eye irritation are classified in Category 2 (irritating to eyes).
According to the CLP Regulation 1272/2008, using the results of animal testing the substance can be classify as a single irritant category (Category 2) according to the criteria, section 3.3, table 3.3.2
If, when applied to the eye of an animal, the substance produces:
- at least in 2 of 3 tested animals, a positive response of:
corneal opacity ≥ 1 and/or iritis ≥ 1, and/or
conjunctival redness ≥ 2 and/or
conjunctival oedema (chemosis) ≥ 2
calculated as the mean scores following grading at 24, 48 and 72 hours after installation of the test material, and which fully reverses within an observation period of 21 days.
The Similar substance 01 produced a positive responses
≥ 1 on corneal opacity,
= 2 on conjunctival redness
= 2 conjunctival oedema (chemosis)
in two or three animals, calculated as the mean of scores at 24, 48, 72 hours.
The damage was fully reversible after 14 days, therefore the substance should be classified, according to the CLP Regulation 1272/2008, as Irritant, Category 2, H319.
However, it should be noted that the tested eyes were not rinsed during the test, therefore an additional study in read across on similar substance 02 was evaluated.
The Similar substance 02 is irritant.
Based on the read-across principle, the results can be considered for the eye irritation/damage assessment of the substance.
According to the paragraph 3.3 of the CLP Regulation n. 1272/2008, the substance is classified
H319: Causes serious eye irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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