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EC number: 701-140-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 23rd of November to 14th of December, 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Study conducted according to internationally accepted guideline.
- Justification for type of information:
- Justification for Read Across is detailed in the endpoint summary and it is further detailed in the report attached to the IUCLID section 13.
Cross-reference
- Reason / purpose for cross-reference:
- read-across source
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Similar substance 01 of Acid Brown 191
- IUPAC Name:
- Similar substance 01 of Acid Brown 191
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
Source: Kleintierrarm Madoerin AG, CH 4414 Fuellinsdorf Switzerland
Age at start of treatment males: 7 weeks, females: 9 weeks
Body weight at start of treatment males: 174- 186 g, females: 152 - 164 g
Identification: by unique cage number and corresponding color-coded spots on the tail.
Randomization: randomly selected at time of delivery in groups of five.
Acclimatization At least one week under laboratory conditions, after veterinary examination.
ENVIRONMENTAL CONDITIONS
Room No: 136
Standard Laboratory Conditions:
Air-conditioned with 10-15 air changes per hour, and hourly monitored environment with temperature 22 ± 3 °C centigrade, relative humidity 40-70 %, 12 hours artificial fluorescent light/12 hours dark, music-light period.
Accommodati on: groups of five in Nakrolon type-3 cages with standard softwood bedding (‘Lignocel’, Schill AG, 4132 Nuttenz, Switzerland).
Diet: pelleted standard Kliba 343
Batch 34/88 rat maintenance diet (‘Kliba’, Klingentalmuehle AG, 4303 Kaiseraugst, Switzerland) available ad libitum.
Analysis for contaminants were performed.
Water: community tap water from Itingen, available ad libitum.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- The animals received a single dose of the test article on a mg/kg body weight base by oral gavage after being fasted for 12 to 18 hours (access to water was not interrupted). Food was again presented approximately one hour after dosing.
- Doses:
- Application Volume/kg body weight: 10 ml at 2000 mg/kg.
- No. of animals per sex per dose:
- 5 males
5 females - Control animals:
- yes
- Details on study design:
- OBSERVATION
Mortality /Viability: Four times during test day 1, and daily during days 2—15;
Body Weights: Test days 1 (pre—administration), 8 and 15.
Symptoms: ach animal was examined for changes in appearance and behavior four times during day 1, and daily during days 2—15.
All abnormalities were recorded: general behaviour, respiration, eye, nose, motility, body posture, motor supsceptibility, skin, various.
Pathology:Necropsies were performed by experienced prosectors.
All animals were necropsied. All animals were killed by intraperitoneal injection of sodium pentobarbitone and discarded.
The following data were recorded on data sheets and transcribed for compilation and analysis:signs and symptoms, mortality, body weights, necropsy, macroscopic findings (on—line). - Statistics:
- The LOGIT-Model could not be applied to the observed rates or death. The toxicity was estimated without use of a statistical model.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- not specified
- Mortality:
- No death occurred during the study
- Clinical signs:
- other: Sedation was observed at 2000 mg/kg and the animals had recovered within 2 observation days.
- Gross pathology:
- Macroscopical examination: no findings noted
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified as harmful/toxic according to the CLP Regulation (EC) No.1272/2008
- Conclusions:
- LD50 > 2000 mg/kg bw
- Executive summary:
Method
The test article was administered to rats of both sexes by oral gavage, at a dose of 2000 mg/kg, according to the OECD Guideline 401.
Observation
The following death rate was observed: 0 % at 2000 mg/kg
The LOGIT-Model could not be applied to these data. The acute oral toxicity of the substance in rats of both sexes, observed over a period of 15 days, was estimated to be greater than 2000 mg/kg.
Sedation was observed at 2000 mg/kg and the animals had recovered within 2 observation days. No macroscopical organ changes were observed.
Results
LD50 > 2000 mg/kg bw
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