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EC number: 700-932-4
CAS number: -
Log BCF from regression-based method: 0.500 (BCF: 3.162 l/kg wet-wt)
According to the REACH Regulation, Annex
IX, Column 2, the substance does not need to be tested due to the low
potential for bioaccumulation (log Kow < 3) and a low potential to cross
biological membranes (high molecular weight, high polarity); furthermore
direct and indirect exposure of the aquatic compartment is unsuitable.
Literature bioaccumulation studies are
available on the analogous substance 04 and 08 and they demonstrated no
bioaccumulation in fish. Bluegills (Lepomis machrochirus) was
exposed to the test item in dynamic flowthrough tankwater systems, in
order to determine at what degree this product accumulate in portions of
the fish, which may be consumed by humans. The concentrations tested
were 1 mg/l in the case of analogous substance 04 and 0.1 mg/l in the
case of analogous substance 08. The exposure period was 70 day for
analogous substance 04 and 35 days for analogous substance 08; the
elimination phase was from 7 to 14 days for both the analogous.
During the tests, fish and water were
periodically sampled and analysed. A further accumulation study using 14C-labeled
analogous substance 08 was performed at concentrations of 0.01 and 0.001
mg/l; exposure phase was of 30 days, while elimination phase of 14 days.
Only sporadic trace concentrations (less
than 0.05 mg/kg) of analogous substances 04 and 08 were present in the
fish at exposure levels of 0.1 and 1 mg/l. In most instances, no
detectable substances were found. The data indicates that there is no
tendency for both the substances to be taken up and stored in the fish.
In the case of the 14C-analogous substance 08, at both the
concentrations tested, the levels of radioactivity found in the fish
were approximately equal to those found in the tankwater throughout
study. Furthermore the absence of accumulated radioactivity demonstrated
that neither parent compound, nor possible metabolites of the substance
are accumulated in fish (Ganz, 1975).
For completeness sake, the estimation of
biodegradation using the BCFBAF v3.01 tool was performed
for each one of the Leucophor 1111X constituents. The Log BCF (from
regression-based method) has been found to be 0.500 (BCF: 3.162 l/kg
wet-wt) in all cases.
All the substances used in a read
across approach are Stilbene derivatives Fluorescent Whitening Agents
salts. They display similar structural and physicochemical properties:
all of them exhibit high degree of dissociation in water and very low
octanol/water partition coefficients because to a higher affinity with
water phase than the octanol one. They are all very soluble in water,
due to the presence of sulphonated groups in the molecules; all of them
are expected to undergo to the same environmental fate.
The read across approach can be
considered as reliable and representative. Further details about the
justification for read across approach are given in the report attached
to the Section 13 of this dossier.
v.3.01 is an application contained in the EpiSuite 4.1, the suite of
physical/chemical property and environmental fate estimation programs
developed by the EPA’s Office of Pollution Prevention Toxics and
Syracuse Research Corporation (SRC).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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