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EC number: 219-268-7 | CAS number: 2399-48-6
Endpoint summary
Administrative data
Description of key information
An acute toxicity study by oral route is available on tetrahydrofurfuryl acrylate. The results showed a LD50 of 928 mg/kg in rats indicating that the test substance is harmful after a single administration by oral route.
No acute toxicity study is available by dermal route and inhalation, because tetrahydrofurfuryl acrylate is a skin corrosive substance.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August - September 1984
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- 1993
- Deviations:
- yes
- Remarks:
- Change in body weight range of test animals at start of treatment
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: kleintierfarm Madoerin AG, CH4414 Fuellinsdorf/ Switzerland
- Age at study initiation: 9-13 weeks
- Weight at study initiation: males = 168-298 g ; females = 146-213 g
- Fasting period before study:
- Housing: groups of 5
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum):ad libitum
- Acclimation period: one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22+/-2
- Humidity (%): 55+/-10
- Air changes (per hr): 10/15
- Photoperiod (hrs dark / hrs light): 12/12 - Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- 2% in distilled water
- Details on oral exposure:
- The animals received the test article on a mg/kg bw base by oral gavage after being fasted for 12 to 18 hours (access to water not interrupted). Food was again presented approximately one hour after dosing.
Volume application : 10 ml, except at the dose of 5000 mg§kg (20 ml) - Doses:
- 600, 1000, 2000, 5000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- The test article was placed info a glass beaker on a tared balance and the vehicle was added. A weight by volume suspension was prepared using a homogenizer.
Homogeneity of the test article in the vehicle was maintained during treatment using a magnetic stirrer. The preparations were made immediately prior to each dosing.
- Duration of observation period following administration: 15 days
- Frequency of observations (mortality and clinical signs): four times during test day 1, and daily during days 2-15
- Frequency of weighing: test days 1 (pre-administration), 8 and 15
- Necropsy of survivors performed: yes - Statistics:
- The LOGIT-Model was applied to estimate the LD50 value. Additionally, the 90, 95 and 99% confidence intervals for the LD50 for each sex and the slope of the concentration response line was estimated.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 928 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 708 - 1 183
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 002 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 634 - < 1 462
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 882 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 344 - < 1 468
- Mortality:
- 600 mg/kg = 1/10 : no mortality in males (0/5), 1 female died at day 7.
1000 mg/kg = 6/10 : 3/5 dead males, on day 2. 3/5 dead females: 2 animals 5h after administration, and one animal at day 2.
2000 mg/kg = 10/10: 5/5 dead males : 1 animal 3 hr after administration, 3 animals 5hr after, and 1 animal at day 2. 5/5 dead females: one female 3hr after administration, 2 females 5h after, and 2 females at day 2.
5000 mg/kg = 10/10 : 5/5 dead males: 1 animal 2 hr after administration, 3 animals 3hr after, and 1 animal 5hr after. 5/5 dead females: one female 2 hr after administration, and 4 females 3 hr after. - Clinical signs:
- other: 600 mg/kg: sedation, abdominal position, curved body position (females), ruffles fur. 1000 mg/kg: sedaction, exophthalmos, emaciation (females), ruffled fur. 2000 mg/kg: sedaction, exophthalmos,abdominal position, curved body position, ruffled fur. 5000 m
- Gross pathology:
- 600 mg/kg: cannibalism (dead), no change in killed animals.
1000 mg/kg: in dead animals, stomach filled with test article (severe), dark-red discolor small intestine. In killed animals: reddened slight small intestine.
2000 mg/kg: Stomach filled with test article (severe); stomach enlarged, severe, filled with test article ; dark-red discolored intestines; slight and reddened small intestines; abdominal cavity filled with clear fluid (2 ml).
5000 mg/kg: Stomach filled with test article (severe) - Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Based on the experimental data, the acute oral LD50 of tetrahydrofurfurylacrylate in rats of both sexes observed for a period of 15 days is 928 mg/kg.
- Executive summary:
The test article Tetrahydrofurfurylacrylate was administered to rats of both sexes by oral gavage at doses from 600 to 5000 mg/kg bw. Five males and five females were exposed by dose. The following death rate was observed : 10% at 600 mg/kg, 60% at 1000 mg/kg, 100% at 2000 and 5000 mg/kg. Based on these data, the Logit-estimation for the acute oral LD50 of tetrahydrofurfurylacrylate in rats of both sexes observed for a period of 15 days is 928 mg/kg (males: 1002 mg/kg, females : 882 mg/kg).
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 928 mg/kg bw
- Quality of whole database:
- The study is considered to be reliable with a klimisch score of 1.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute oral toxicity :
The test article Tetrahydrofurfurylacrylate was administered to rats of both sexes by oral gavage at doses from 600 to 5000 mg/kg bw. Five males and five females were exposed by dose. The following death rate was observed : 10% at 600 mg/kg, 60% at 1000 mg/kg, 100% at 2000 and 5000 mg/kg. Based on these data, the Logit-estimation for the acute oral LD50 of tetrahydrofurfurylacrylate in rats of both sexes observed for a period of 15 days is 928 mg/kg (males: 1002 mg/kg, females : 882 mg/kg).
Justification for classification or non-classification
Based on the oral acute toxicity study, tetrahydrofurfuryl acrylate should be classified as Harmful if swallowed (Acute toxicity 4, H302).
Justification: The oral LD50 is between 300 and 2000 mg/kg (928 mg/kg).
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