Registration Dossier
Registration Dossier
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EC number: 310-115-0 | CAS number: 102506-09-2
Endpoint summary
Administrative data
Description of key information
An oral LD50 value of >2000 mg/kg bw was reported for [cyclohexane-1,2-diylbis[nitrilobis(methylene)]]tetrakisphosphonic acid, sodium salt in a reliable limit test conducted according to the now deleted OECD test guideline 401, and in compliance with GLP (Safepharm, 1992).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The key acute oral toxicity study (Safepharm, 1992) was conducted according to the now deleted OECD test guideline 401. Sprague-Dawley rats (5 animals/sex) were given the test substance as an oral gavage dose of 2000 mg/kg bw. The animals were then observed for mortality and clinical signs of toxicity for 14 days. A necropsy examination was conducted on each animal following the 14 day observation period. There were no deaths, no signs of toxicity, and growth and necropsy findings were normal. The LD50 for male and female animals was therefore >2000 mg/kg bw.
There are no acute toxicity studies for the dermal and inhalation routes of exposure.
Justification for selection of
acute toxicity – oral endpoint
The key study was conducted according to the now deleted OECD test
guideline 401 and in compliance with GLP.
Justification for classification or non-classification
Based on the acute oral toxicity study results classification for acute toxicity is not required for [cyclohexane-1,2-diylbis[nitrilobis(methylene)]]tetrakisphosphonic acid, sodium salt under Regulation (EC) 1272/2008.
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