Lavender, Lavandula hybrida, ext.

Eye irritation

Administrative data

Endpoint:

eye irritation, other

Remarks:

Classification based on calculation rules for mixtures of the CLP Regulation

Type of information:

calculation (if not (Q)SAR)

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

accepted calculation method

Data source

Reference

Reference Type:

other: Guidance

Title:

Guidance on the Application of the CLP Criteria - Guidance to Regulation (EC) No 1272/2008 on classification, labelling and packaging (CLP) of substances and mixtures

Author:

ECHA

Year:

2017

Bibliographic source:

ECHA-17-G-21-EN

Materials and methods

Test guideline

Qualifier:

no guideline required

Principles of method if other than guideline:

Classification based on calculation rules for mixtures of the CLP Regulation

Test material

Test material information

Constituent 1

Reference substance name:

Linalool

EC Number:

201-134-4

EC Name:

Linalool

Cas Number:

78-70-6

Molecular formula:

C10H18O

IUPAC Name:

3,7-dimethylocta-1,6-dien-3-ol

Constituent 2

Reference substance name:

Linalyl acetate

EC Number:

204-116-4

EC Name:

Linalyl acetate

Cas Number:

115-95-7

Molecular formula:

C12H20O2

IUPAC Name:

3,7-dimethylocta-1,6-dien-3-yl acetate

Test material form:

liquid

Results and discussion

In vitro

Results

Irritation parameter:

other: Classification

Remarks on result:

other: Eye damage category 2

Applicant's summary and conclusion

Interpretation of results:

Category 2 (irritating to eyes) based on GHS criteria

Conclusions:

The registered substance has more than 10% of its constituents classified as Eye irritant Category 2 and should be classified as a skin irritant without further testing according to the rules for classification of mixtures of Regulation (EC) No 1272/2008.

Executive summary:

The NCS is composed of several identified constituents and in that, it can be considered as a mixture according to the definition of the CLP Regulation. The decision logic for classification of mixtures from the ECHA Guidance on the Application of the CLP Criteria (2015) was used to determine the serious eye damage/ eye irritant hazard of the registered substance. The decision of classification as irritant to the eyes was based on existing data on constituents (additivity principles):the registered substance has more than 10% of its constituents classified as Eye irritant Category 2 and should be classified as a skin irritant without further testing according to the rules for classification of mixtures of Regulation (EC) No 1272/2008.

Constituent	CAS	Classification	Source
Terpinol-4	562-74-3	H319	ECHA C&L inventory–self classification
Linalool	78-70-6	H319	ECHA C&L inventory - self classification
Linalyl acetate	115-95-7	H319	ECHA C&L inventory - self classification

Source: ECHA disseminated dossiersor self classification