Lavender, Lavandula hybrida, ext.

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

07 December 2016-22 March 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

The study was conducted according to an internationally recognised method, and under GLP. The substance is considered to be adequately characterised. Therefore full validation applies.

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7220 (Boiling Point / Boiling Range)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

UK GLP compliance programme (inspected on 05 July 2016 / signed on 28 October 2016)

Type of method:

differential scanning calorimetry

Key result

Boiling pt.:

206 °C

Atm. press.:

99 kPa

Decomposition:

ambiguous

Remarks on result:

other: The test item has been determined to partially boiled with decomposition from 206 ± 2°C (479 ± 2 K) at 99.0 kPa.

Results

The thermograms and thermographic data for determinations 1 and 2 are shown in some Figures and tables (please, see the experimental report).

Determination 1: Weight change = 93% ; Residue : Black solid around periphery;

Determination 2: Weight change = 88% ; Residue : Black solid around periphery;

Determination 3: Weight change = 73% ; Residue : Amber solid around periphery;

Determination 4: Weight change = 75% ; Residue : Amber solid around periphery;

Determination 5: Weight change = 71% ; Residue : Black / dark brown solid around periphery;

Determination 6: Weight change = 72% ; Residue : Black / dark brown solid around periphery;

Thermographic Data

Thermal event	Interpretation	Temperature
		Determination 1		Determination 2
		°C	K	°C	K
Endotherm onset temperature	Boiling with potential decomposition	207.89	481.04	206.50	479.65
Thermal event	Interpretation	Determination 3		Determination 4
		°C	K	°C	K
Endotherm onset temperature	Boiling with potential decomposition	196.20	469.35	205.10	478.25

Determinations 5 and 6 used for decomposition analysis only.

Atmospheric pressure:

Determinations 1 and 2: 99.2 kPa

Determinations 3 and 4: 98.8 kPa

Determination 3 was not included in the final temperature, outlying result.

A black solid around the periphery was observed as a post thermal heating residue, which was considered as a sign of decomposition. Similar thermographic profiles were obtained using air and nitrogen atmospheres. This indicated that the decomposition was probably thermal and not oxidative.

Considering that the substance is not totally vaporised after heating (weight change between 73 and 75% in determinations 3 and 4) we have considered that the substance partially boiled with decomposition from 206 ± 2°C (479 ± 2 K).

Conclusions:

The test item has been determined to partially boiled with decomposition from 206 ± 2°C (479 ± 2 K) at 99.0 kPa.

Executive summary:

The boiling point of the test substance was determined under GLP by differential scanning calorimetry (DSC) according to EU A2 guideline.

Four main runs were performed under air and the mean of three measurements was retained.

As the weight change varied from 71 to 93% (pending on the temperature program), the test item was considered to boil partially only. In addition, a dark residue was observed at the end of analysis, which was considered as a sign of decomposition. Finally, two runs performed under nitrogen showed that decomposition was probably thermal and not oxidative.

Description of key information

The test item has been determined to partially boiled with decomposition from 206 ± 2°C (479 ± 2 K) at 99.0 kPa.

Key value for chemical safety assessment

Boiling point at 101 325 Pa:

206 °C

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. It is considered as a key study.

The boiling point of the test substance was determined by differential scanning calorimetry (DSC).

Four main runs were performed under air and the mean of three measurements was retained.

As the weight change varied from 71 to 93% (pending on the temperature program), the test item was considered to boil partially only. In addition, a dark residue was observed at the end of analysis, which was considered as a sign of decomposition. Finally, two runs performed under nitrogen showed that decomposition was probably thermal and not oxidative.