Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-124-5 | CAS number: 103-56-0
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data from peer reviewed journal
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Fragrance material review on cinnamyl propionate
- Author:
- S.P. Bhatia a, G.A. Wellington , J. Cocchiara , J. Lalko , C.S. Letizia , A.M. Api
- Year:
- 2 007
- Bibliographic source:
- Food and Chemical Toxicology 45 (2007) S1–S23
- Reference Type:
- secondary source
- Title:
- To study the skin sensitization of cinnamyl propionate
- Author:
- D. L. J. OPDYKE
- Year:
- 1 974
- Bibliographic source:
- Food and Cosmetics Toxicology. Vol. 12, Pg. 859, 1974
- Reference Type:
- review article or handbook
- Title:
- A toxicologic and dermatologic assessment of related esters and alcohols of cinnamic acid and cinnamyl alcohol when used as fragrance ingredients
- Author:
- The RIFM Expert Panel,D. Belsito , D. Bickers , M. Bruze , P. Calow , H. Greim , J.M. Hanifin , A.E. Rogers , J.H. Saurat , I.G. Sipes , H. Tagami
- Year:
- 2 007
- Bibliographic source:
- Food and Chemical Toxicology, 45, (2007), S1–S23
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- The skin sensitization study of cinnamyl propionate was performed on human.
- GLP compliance:
- not specified
- Type of study:
- patch test
- Justification for non-LLNA method:
- No data available
Test material
- Reference substance name:
- Cinnamyl propionate
- EC Number:
- 203-124-5
- EC Name:
- Cinnamyl propionate
- Cas Number:
- 103-56-0
- Molecular formula:
- C12H14O2
- IUPAC Name:
- cinnamyl propionate
- Test material form:
- liquid
- Details on test material:
- Name of the test chemical:3-phenylprop-2-en-1-yl propionate, Cinnamyl propionate
Molecular Formula: C12H14O2
Molecular Weight: 190.241 g/mol
InChI: 1S/C12H14O2/c1-2-12(13)14-10-6-9-11-7-4-3-5-8-11/h3-9H,2,10H2,1H3/b9-6+
Substance Type: Organic
Physical State: Liquid
Constituent 1
- Specific details on test material used for the study:
- Name of the test chemical:3-phenylprop-2-en-1-yl propionate, Cinnamyl propionate
Molecular Formula: C12H14O2
Molecular Weight: 190.241 g/mol
InChI: 1S/C12H14O2/c1-2-12(13)14-10-6-9-11-7-4-3-5-8-11/h3-9H,2,10H2,1H3/b9-6+
Substance Type: Organic
Physical State: Liquid
In vivo test system
Test animals
- Species:
- other: Human
- Strain:
- not specified
- Sex:
- male
- Details on test animals and environmental conditions:
- No data available
Study design: in vivo (non-LLNA)
Induction
- Route:
- epicutaneous, occlusive
- Vehicle:
- petrolatum
- Concentration / amount:
- 4%
- Day(s)/duration:
- 48hr
Challenge
- No.:
- #1
- Route:
- epicutaneous, occlusive
- Vehicle:
- petrolatum
- Concentration / amount:
- 4%
- Day(s)/duration:
- 48hr
- No. of animals per dose:
- 25
- Details on study design:
- Details on study design
RANGE FINDING TESTS:
MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 5
- Exposure period:48hr
- Test groups:25
- Control group:00
- Site: Forearms
- Frequency of applications: five alternate-day
- Duration:10 days
- Concentrations:4%
B. CHALLENGE EXPOSURE
- No. of exposures:1
- Day(s) of challenge:10days after last induction application
- Exposure period:48hr
- Test groups:25
- Control group:00
- Site: fresh site
- Concentrations:4%
- Evaluation (hr after challenge):24hr
Other: Patch sites were pretreated for 24 h with 5% aqueous sodium lauryl sulfate (SLS) under occlusion before induction exposure while Challenge applications were preceded by 1-hour applications of 10% aqueous SLS under
occlusion - Challenge controls:
- No data available
- Positive control substance(s):
- not specified
Study design: in vivo (LLNA)
- Statistics:
- No data available
Results and discussion
- Positive control results:
- No data available
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 4%
- No. with + reactions:
- 0
- Total no. in group:
- 25
- Clinical observations:
- No skin sensitization reaction was observed
- Remarks on result:
- no indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- other: not sensitizing
- Conclusions:
- The cinnamyl propionate (103-56-0) was considered to be as not sensitizing in human.
- Executive summary:
Skin sensitizing test was performed in 25 human at 4% concentration in petrolatum.The induction given on five alternate-days for 48hr on forearm under occlusion. Patch sites were pretreated for 24 h with 5% aqueous sodium lauryl sulfate (SLS) under occlusion before induction exposure. After 10 days rest period, challenge application given for 48hr having same concentration as induction exposure. Evaluation done after 24hr. Challenge applications were preceded by 1-hour applications of 10% aqueous SLS under occlusion.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
