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Toxicity to microorganisms

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Reference
Endpoint:
activated sludge respiration inhibition testing
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1987
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Justification for type of information:
None
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
Deviations:
not specified
GLP compliance:
no
Specific details on test material used for the study:
Code number: FAT 40278/A
Analytical monitoring:
no
Vehicle:
not specified
Test organisms (species):
activated sludge, domestic
Test type:
not specified
Water media type:
freshwater
Limit test:
no
Total exposure duration:
3 h
Test temperature:
20 ± 2 °C
Nominal and measured concentrations:
Test concentrations: 400. 128 and 40 mg/l of the test substance.
100, 32 and 10 mg/l of the reference substance.
Reference substance (positive control):
yes
Remarks:
3,5-Dichlorophenol
Key result
Duration:
3 h
Dose descriptor:
IC50
Effect conc.:
> 400 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Details on results:
No inhibition was seen at any of the test concentrations.
Results with reference substance (positive control):
The IC50 (3 h) of the reference substance 3,5-Dichlorophenol: 19 mg/l
Validity criteria fulfilled:
yes
Conclusions:
IC50 (3 h) of the test substance FAT 40278/A was determined to be >400 mg/l.
Executive summary:

The toxicity of FAT 40278/A to activated sludge was determined in a 3-h respiration inhibition test guideline similar to OECD Guideline No. 209 (Method B.21). The test substance concentrations tested were 400, 128 and 40 mg/l. No inhibition was seen at any of the test concentrations. Based ont he findings of the study, IC50 (3 h) of the test substance FAT 40278/A was determined to be >400 mg/l.

Description of key information

The toxicity of FAT 40278/A to activated sludge was determined in a 3-h respiration inhibition test guideline similar to OECD Guideline No. 209 (Method B.21). The test substance concentrations tested were 400, 128 and 40 mg/l. No inhibition was seen at any of the test concentrations. Based ont he findings of the study, IC50(3 h) of the test substance FAT 40278/A was determined to be >400 mg/l

Key value for chemical safety assessment

EC50 for microorganisms:
400 mg/L

Additional information