Registration Dossier
Registration Dossier
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EC number: 243-632-4 | CAS number: 20241-76-3
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Justification for type of information:
- None
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Deviations:
- not specified
- GLP compliance:
- no
- Specific details on test material used for the study:
- Code number: FAT 40278/A
- Analytical monitoring:
- no
- Vehicle:
- not specified
- Test organisms (species):
- activated sludge, domestic
- Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
- Test temperature:
- 20 ± 2 °C
- Nominal and measured concentrations:
- Test concentrations: 400. 128 and 40 mg/l of the test substance.
100, 32 and 10 mg/l of the reference substance. - Reference substance (positive control):
- yes
- Remarks:
- 3,5-Dichlorophenol
- Key result
- Duration:
- 3 h
- Dose descriptor:
- IC50
- Effect conc.:
- > 400 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Details on results:
- No inhibition was seen at any of the test concentrations.
- Results with reference substance (positive control):
- The IC50 (3 h) of the reference substance 3,5-Dichlorophenol: 19 mg/l
- Validity criteria fulfilled:
- yes
- Conclusions:
- IC50 (3 h) of the test substance FAT 40278/A was determined to be >400 mg/l.
- Executive summary:
The toxicity of FAT 40278/A to activated sludge was determined in a 3-h respiration inhibition test guideline similar to OECD Guideline No. 209 (Method B.21). The test substance concentrations tested were 400, 128 and 40 mg/l. No inhibition was seen at any of the test concentrations. Based ont he findings of the study, IC50 (3 h) of the test substance FAT 40278/A was determined to be >400 mg/l.
Reference
Description of key information
The toxicity of FAT 40278/A to activated sludge was determined in a 3-h respiration inhibition test guideline similar to OECD Guideline No. 209 (Method B.21). The test substance concentrations tested were 400, 128 and 40 mg/l. No inhibition was seen at any of the test concentrations. Based ont he findings of the study, IC50(3 h) of the test substance FAT 40278/A was determined to be >400 mg/l
Key value for chemical safety assessment
- EC50 for microorganisms:
- 400 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
