Registration Dossier
Registration Dossier
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EC number: 243-632-4 | CAS number: 20241-76-3
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Refer chapter 13 for the detailed read across justification.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Type:
- log Koc
- Value:
- > 5.63 dimensionless
- pH:
- 5.5
- Temp.:
- 30 °C
- Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient (Koc) of the tsource substance at pH 5.5 has been determined to be greater than 4.27E+05, log10 Koc greater than 5.63.
- Executive summary:
The determination of adsorption coeffcient of the source substance was carried out using the HPLC screening method, designed to be compatible with EU Method C.19 and OECD Guideline 121, in compliance with GLP. The test system utilized a high performance liquid chromatograph. A commercially available cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties was used. The adsorption coefficient (Koc) of the test item at pH 5.5 has been determined to be greater than 4.27E+05, log10 Koc greater than 5.63. These values indicate that the test item will be immobile at pH 5.5.
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Refer chapter 13 for the detailed read across justification.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Type:
- log Koc
- Value:
- > 3.91 - ca. 5.63 dimensionless
- pH:
- 7
- Temp.:
- 30 °C
- Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient (Koc) of the source substance at pH 7 has been determined to be in the range 8.03+E3 to greater than 4.27E+5, log10 Koc in the range 3.91 to greater than 5.63.
- Executive summary:
The adsorption coefficient of the source substance, FAT 92504/C, TE has been determined to be greater than 4.27 x 105, log10 Koc greater than 5.63, at pH 5.5, and in the range 8.03 x 103 to greater than 4.27 x 105, log10 Koc in the range 3.91 to greater than 5.63, at pH 7, using the HPLC screening method, designed to be compatible with Method C.19 Adsorption Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 121 of the OECD Guidelines for Testing of Chemicals, 22 January 2001. These values indicate that the test item will be immobile.
Referenceopen allclose all
Description of key information
Currently, no study assessing the adsorption coefficient for Disperse Blue 077 is available. Hence, a read across was performed with Disperse Blue 054/077.
The determination of adsorption coeffcient of the source substance was carried out using the HPLC screening method, designed to be compatible with EU Method C.19 and OECD Guideline 121, in compliance with GLP. The test system utilized a high performance liquid chromatograph. A commercially available cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties was used. As the test item has estimated (ACD/Labs I-Lab 2.0) pKa’s of approximately 5.2 and 10.4 (where the two OH groups are opposite each other, and approximately 4.3 and 10.3 (where the two OH groups are adjacent to each other), it was considered appropriate to perform testing at pH 5.5 and pH 7. The adsorption coefficient (Koc) of the test item at pH 7 has been determined to be in the range 8.03 x 103to greater than 4.27 x 105, log10 Koc in the range 3.91 to greater than 5.63. These values indicate that the test item will be immobile at pH 7. The adsorption coefficient (Koc) of the test item at pH 5.5 has been determined to be greater than 4.27x 105, log10 Koc greater than 5.63. These values indicate that the test item will be immobile at pH 5.5.
[LogKoc: 5.63]
Key value for chemical safety assessment
- Koc at 20 °C:
- 42 700
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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