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EC number: 426-730-3 | CAS number: 123439-82-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant, guideline study, available as unpublished report, fully adequate for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 123439-82-7
- Cas Number:
- 123439-82-7
- IUPAC Name:
- 123439-82-7
- Reference substance name:
- Tetrammine platinum (II) hydrogen carbonate
- IUPAC Name:
- Tetrammine platinum (II) hydrogen carbonate
- Test material form:
- solid
- Remarks:
- powder
- Details on test material:
- - Description: white powder
Constituent 1
Constituent 2
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Sampling was conducted on old and new media. Water samples were taken form the control and each replicate test vessel at 0, 24 and 96 hours for quantitative analysis.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: an amount of test material (4.00 g) was dispersed in reverse osmosis water with the aid of ultrasonication and the volume was adjusted to 1 L to give a 4.00 g/L stock solution. An aliquot of 500 mL of this stock solution was dispersed in dechlorinated tap water and the volume was adjusted to 20 L in order to give the 100 mg/L test concentration.
- Control: dechlorinated tap water without the test item
Test organisms
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- TEST ORGANISM
- Common name: Rainbow trout
- Source: Parkwood Trout Farm, Harrietsham, Kent, UK
- Age at study initiation: juvenilesrainbow trout
- Length at study initiation (mean and SD): 4.8 cm (SD=0.4)
- Weight at study initiation (mean and SD): 1.47 cm (SD=0.39)
- Feeding during test: no feeding during test or 24 hours prior to the test
ACCLIMATION
- Acclimation period: 7 days
- Acclimation conditions (same as test or not): same as test
- Type and amount of food: commercial trout pellets
- Health during acclimation (any mortality observed): zero mortality
Fish were maintained in-house since 14 October 1996 in a glass fibre tank with "single pass" water renewal system. Fish were acclimatised to test conditions for 7 days prior to test and the lighting cycle was controlled to give a 16 hours of light and 8 hours dark.
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 100 mg/l as CaCO3
- Test temperature:
- 13 - 14 °C
- pH:
- 7.5 - 8.1
- Dissolved oxygen:
- 8.7 - 9.4 mg/L
- Nominal and measured concentrations:
- Nominal concentrations: 100 mg test item/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: glass vessels (covered)
- Material, size, headspace, fill volume: 20 L
- Aeration: areation was done via narrow bore glass tubes.
- Renewal rate of test solution (frequency/flow rate): daily
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 1
- Biomass loading rate: 0.74 g body weight/L
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: laboratory tap water dechlorinated by passage through an activated carbon filter
- Total Hardness: 100 mg/L as CaCO3
- Metals (mean values): calcium 81 mg/L, magnesium 14 mg/L, sodium 56 mg/L, potassium 4.4 mg/L, iron 58 mg/L, manganese < 6 μg/L, aluminum < 20 μg/L, copper 10 μg/L, zinc 20 μg/L, lead < 7 μg/L, cadmium < 0.5 μg/L, silver < 0.2 μg/L, boron 100 μg/L, barium 80 μg/L, arsenic < 1 μg/L, chromium < 5 μg/L, nickel 5 μg/L
- Alkalinity: 137 mg/L (mean)
- Conductivity: 627 μS/cm (mean)
OTHER TEST CONDITIONS
- Photoperiod: 16 light : 8 dark
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
Any mortalities abd sub-lethal effects of exposure were recorded at 3, 6, 24, 48, 72 and 96 hours after the start of the exposure. The criteria of death were taken to be the absence of both respiratory movement and response to physical stimulation.
TEST CONCENTRATIONS
A range-range finiding study was initially performed at 1, 10 and 100 mg/L test concentrations.
A limit test was conducted after the range finding test and it consisted of a test concentration of 100 mg/L. - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 50.64 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- element
- Remarks:
- Pt
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 50.64 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- element
- Remarks:
- Pt
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: sub-lethal effects
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 50.64 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- element
- Remarks:
- Pt
- Basis for effect:
- other: sub-lethal effects
- Details on results:
- - Behavioural abnormalities: none
- Mortality of control: zero mortality
- The NOEC was based upon zero mortalities and the absence of any sub-lethal effects of exposure at 100 mg test item/L - Reported statistics and error estimates:
- An estimate of the LC50 and NOEC values was given by inspection of the mortality data.
Any other information on results incl. tables
- Sublethal observations / clinical signs:
Table 1. Cumulative mortality data at 3, 6, 24, 48, 72 and 96 hours of exposure to the test item for Oncorhyncus mykiss
Nominal concentration (mg/L) Cumulative mortality (Initial population - 10) % mortality 3 hours
6 hours
24 hours
48 hours
72 hours
96 hours
96 hours Control
0
0
0
0
0
0
0 100 (Replicate 1)
0
0
0
0
0
0
0 100 (Replicate 2)
0
0
0
0
0
0
0
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Based on nominal concentrations, the 96-hour LC50 of tetraammineplatinum(2+) hydrogencarbonate to rainbow trout was greater than 100 mg test item/L corresponding to >50.64 mg Pt/L. Correspondingly the NOEC was greater than or equal to 100 mg test item /L (≥ 50.64 mg Pt/L).
- Executive summary:
An acute Oncorhyncus mykiss study is available for tetraammineplatinum(2+) hydrogencarbonate. The study is reliable without restrictions, being GLP-compliant and having followed standard test guidelines (OECD 203 and EU Method C.1).
A semi-static test procedure was followed, and test solutions were renewed every 24 hours. Based on the range-finding study, a limit test was conducted at a nominal test concentration of 100 mg test item/L, and this was analysed using HPLC. Measured test concentrations ranged from 96 % to 101 % of nominal, and therefore results were based on nominal concentrations. The 96-hour LC50 was determined to be >100 mg test item/L corresponding to >50.64 mg Pt/L. The 96-hour NOEC was determined to be ≥ 100 mg test item/L (≥ 50.64 mg Pt/L).
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