Registration Dossier
Registration Dossier
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EC number: 204-246-1 | CAS number: 118-33-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from authoritative database
Data source
Referenceopen allclose all
- Reference Type:
- other: Authoritative database
- Title:
- RTECS Number: CB6680000
- Author:
- RTECS database
- Year:
- 2 017
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances); "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1329, 1986.
- Reference Type:
- publication
- Title:
- "Prehled Prumyslove Toxikologie; Organicke Latky"
- Author:
- Marhold, J.
- Year:
- 1 986
- Bibliographic source:
- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 -,1059,1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: refer below
- Principles of method if other than guideline:
- The acute toxicity study was conducted to evaluate the toxic effects of administration of 6-aminonaphthalene-1,3-disulphonic acid (CAS No. 118-33-2) in rat by the oral route.
- GLP compliance:
- not specified
- Test type:
- other: No data available
- Limit test:
- no
Test material
- Reference substance name:
- 6-aminonaphthalene-1,3-disulphonic acid
- EC Number:
- 204-246-1
- EC Name:
- 6-aminonaphthalene-1,3-disulphonic acid
- Cas Number:
- 118-33-2
- Molecular formula:
- C10H9NO6S2
- IUPAC Name:
- 6-aminonaphthalene-1,3-disulfonic acid
- Test material form:
- solid
- Details on test material:
- - Name of test material:6 amino-1,3 naphthalene –disulfonic acid
- Molecular formula: C10H9NO6S2
- Molecular weight: 303.314 g/mole
- Smiles notation: c12c(cc(S(O)(=O)=O)cc1S(O)(=O)=O)cc(N)cc2
- InChl: 1S/C10H9NO6S2/c11-7-1-2-9-6(3-7)4-8(18(12,13)14)5-10(9)19(15,16)17/h1-5H,11H2,(H,12,13,14)(H,15,16,17)
- Substance type: Organic
- Physical state: Solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: 6-aminonaphthalene-1,3-disulphonic acid
- Molecular formula: C10H9NO6S2
- Molecular weight: 303.314
- Smiles notation: c12c(cc(S(O)(=O)=O)cc1S(O)(=O)=O)cc(N)cc2
-InChl: 1S/C10H9NO6S2/c11-7-1-2-9-6(3-7)4-8(18(12,13)14)5-10(9)19(15,16)17/h1-5H,11H2,(H,12,13,14)(H,15,16,17)
- Substance type: Organic
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 2000 mg/kg bw (2 gm/kg)
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality observed
- Mortality:
- 50% mortality observed at 2000.0 mg/kg bw in treated rats.
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The acute toxicity study was conducted to evaluate the toxic effects of administration of 6-aminonaphthalene-1,3-disulphonic acid (CAS No. 118-33-2) in rat by the oral route. 50% mortality was observed at 2000 mg/kg bw in treated rats. Therefore, the acute oral median lethal dose (LD50) of 6-aminonaphthalene-1,3-disulphonic acid in rat was observed to be 2000 mg/kg b.wt.
- Executive summary:
The acute toxicity study was conducted to evaluate the toxic effects of administration of 6-aminonaphthalene-1,3-disulphonic acid (CAS No. 118-33-2) in rat by the oral route. 50% mortality was observed at 2000 mg/kg bw in treated rats. Therefore, the acute oral median lethal dose (LD50) of 6-aminonaphthalene -1,3-disulphonic acid in rat was observed to be 2000 mg/kg b.wt. Thus, according to CLP criteria for acute toxicity rating for the chemicals, it infers that 6-aminonaphthalene-1,3-disulphonic acid (CAS No. 118-33-2) can be classify under category 4 compound at the tested dose level of 2000.0 mg/kg body weight.
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