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EC number: 204-486-7 | CAS number: 121-61-9
Endpoint summary
Administrative data
Description of key information
Bioaccumulation: aquatic/sediment
BCFBAF model (v3.01) of Estimation Programs Interface (EPI Suite, 2017) was used to predict the bioconcentration factor (BCF) of test chemical N-(4-sulfamoylphenyl)acetamide (CAS No. 121 -61 -9).The bioconcentration factor (BCF) of N-(4-sulfamoylphenyl)acetamide was estimated to be 3.162 L/kg whole body w.w (at 25 deg C) which does not exceed the bio concentration threshold of 2000, indicating that the chemical N-(4-sulfamoylphenyl)acetamide is not expected to bioaccumulate in the food chain.
Additional information
Bioaccumulation: aquatic/sediment
Various predicted data for the target compound N-(4-sulfamoylphenyl)acetamide (CAS No. 121-61-9) and supporting weight of evidence study for its read across substance were reviewed for the bioaccumulation end point which are summarized as below:
In aprediction done using theBCFBAF Program(v3.01) of Estimation Programs Interface (EPI Suite, 2017) was used to predict the bioconcentration factor (BCF) of test chemical N-(4-sulfamoylphenyl)acetamide (CAS No. 121 -61 -9).The bioconcentration factor (BCF) of N-(4-sulfamoylphenyl)acetamide was estimated to be 3.162 L/kg whole body w.w (at 25 deg C).
In an another prediction done by using Bio-concentration Factor (v12.1.0.50374) module ACD (Advanced Chemistry Development)/I-Lab predictive module, 2017), theBCF over the entire pH scale (pH 1 -14) of the test substance N-(4-sulfamoylphenyl)acetamide (CAS no. 121 -61 -9) was estimated to be 1.
Bioconcentration Factor (BCF) of test chemical N-(4-sulfamoylphenyl)acetamide (CAS no. 121 -61 -9) was estimated using Chemspider database(ChemSpider, 2017). The bioconcentration factor of test substance N-(4-sulfamoylphenyl)acetamide was estimated to be 1 at both pH 5.5 and 7.4, respectively.
Another predicted data was estimated usingSciFinder database (American Chemical Society (ACS), 2017) was used for predicting the bioconcentration factor (BCF) of test chemical N-(4-sulfamoylphenyl)acetamide(CAS No. 121-61-9). The bioconcentration factor (BCF) of N-(4-sulfamoylphenyl)acetamide was estimated to be 1(at 25 deg C).
From CompTox Chemistry Dashboard using OPERA (OPEn (quantitative) structure-activity Relationship Application) V1.02 model in which calculation based on PaDEL descriptors (calculate molecular descriptors and fingerprints of chemical), the bioaccumulation i.e BCF for test substance N-(4-sulfamoylphenyl)acetamide was estimated to be 1.97 dimensionless . The predicted BCF result based on the 5 OECD principles. Thus based on the result it is concluded that the test substance N-(4-sulfamoylphenyl)acetamide is non-bioaccumulative in nature.
In a supporting weight of evidence study from authoritative database (J-CHECK, 2017) for the read across chemical sodium 4-acetamidobenzene-1-sulfonate (CAS no. 6034-54-4), bioaccumulation experiment was conducted on test organism Cyprinus carpio for 6 weeks for evaluating the bioconcentration factor (BCF value) of read across substance sodium 4-acetamidobenzene-1-sulfonate under static conditions. The study was performed according to other guideline "Bioaccumulation test of a chemical substance in fish or shellfish" provided in "the Notice on the Test Method Concerning New Chemical Substances". Cyprinus carpio was used as a test organism for the study. Details on analytical methods involve the recovery ratio: Test water: 1st concentration area: 83.9%, 2nd concentration area : 82.4 %, Fish : 88.1 %, Limit of detection : Fish: 0.38 ppm. Test chemical nominal conc. used for the study were1mg/l and 0.1 mg/l, respectively. Range finding study involve the TLm (48 hr) > 10000 mg/l on Rice fish (Oryzias latipes). Lipid content of the test organism was determined to be 2.8%. The bioconcentration factor (BCF value) of substance sodium 4-acetamidobenzene-1-sulfonate on Cyprinus carpio was determined to be ≤ 0.43 L/kg at a conc. of 1 mg/l and ≤ 3.8 L/Kg at a conc. of 0.1 mg/l, respectively.
For the read across chemical 4'-Aminoacetanilide (CAS no. 122-80-5), bioaccumulation study was conducted on test organism Cyprinus carpio for 28 days for evaluating the bioconcentration factor (BCF value) of substance 4'-Aminoacetanilide under static conditions (J-CHECK, 2017). The study was performed according to “OECD Guideline 305 (Bioconcentration: Flow-through Fish Test)” and other guideline "Bioaccumulation test of a chemical substance in fish or shellfish" provided in "the Notice on the Test Method Concerning New Chemical Substances", respectively. Cyprinus carpio was used as a test organism for the study. Details on analytical methods involve the recovery ratio: Fish: 68.9%, - Limit of quantitation: Test water: 1st concentration area : 5.6µg/l, 2nd concentration area : 0.56µg/l, Fish : 140 ng/g. Test chemical nominal conc. used for the study were 0.2 mg/l and 0.02 mg/l, respectively. Range finding study involve the LC50 (96 hr) > 500 mg/l on Rice fish (Oryzias latipes). Lipid content of the test organism was determined to be 3.9 and 4.05% at the start and end of exposure. The bioconcentration factor (BCF value) of substance 4'-Amino acetanilide on Cyprinus carpio was determined to be ≤ 0.71 L/kg at a conc. of 0.2 mg/l and ≤ 7.2 L/Kg at a conc. of 0.02 mg/l, respectively.
Another bioaccumulation study in fish was conducted for estimating the BCF (bioaccumulation factor) value of read across chemical 4'-Hydroxyacetanilide (CAS no. 103-90-2) (HSDB, 2017). The bioaccumulation factor (BCF) value was calculated using a log Kow of 0.46 and a regression equation. The estimated BCF (bioaccumulation factor) value of read across chemical 4'-Hydroxyacetanilide in fish was determined to be 3 dimensionless.
On the basis of above results for target chemical N-(4-sulfamoylphenyl)acetamide (from EPI suite, ACD labs,ChemSpider, SciFinder database and CompTox Chemistry Dashboard, 2017) and for its read across substance (from authoritative database J-CHECK and HSDB, 2017), it can be concluded that the BCF value of test substance N-(4-sulfamoylphenyl)acetamide ranges from 1 – 3.162 which does not exceed the bioconcentration threshold of 2000, indicating that the chemical N-(4-sulfamoylphenyl)acetamide is not expected to bioaccumulate in the food chain.
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