Registration Dossier
Registration Dossier
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EC number: 200-267-5 | CAS number: 56-34-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer-review journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Tetraethyl ammonium chloride Acute and chronic toxicity in experimental animals.
- Author:
- O.M .Gruhzit.R.A. Fisken and B.J. Cooper
- Year:
- 1 948
- Bibliographic source:
- Journal of Pharmacology and Experimental Therapeutics. Vol. 92,Pg. 103, 1948
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: As mention below
- Principles of method if other than guideline:
- Acute oral toxicity study of N, N, N-triethylethanaminium chloride was performed in Rat
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Reference substance 002
- Cas Number:
- 56-34-8
- Molecular formula:
- C8H20N.CI
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material (as cited in study report):Tetraethylammonium chloride
- Molecular formula :C8H20N.CI
- Molecular weight :165.706 g/mole
- Substance type:organic
- Physical state:Crystalline powder
- Purity:No data available
- Impurities (identity and concentrations):No data available
Constituent 1
- Specific details on test material used for the study:
- Name of test material (as cited in study report):Tetraethylammonium chloride
- Molecular formula :C8H20N.CI
- Molecular weight :165.706 g/mole
- Substance type:organic
- Physical state:Crystalline powder
-Purity:No data available
- Impurities (identity and concentrations):No data available
Test animals
- Species:
- rat
- Strain:
- other: Albino
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- water
- Details on oral exposure:
- Details on exposure
VEHICLE
- Concentration in vehicle: 40.6% test substance dissolved in distilled water
- Amount of vehicle (if gavage): No data available
- Justification for choice of vehicle: Readily dissolved in water
- Lot/batch no. (if required): No data available
- Purity: No data available
MAXIMUM DOSE VOLUME APPLIED: No data available
DOSAGE PREPARATION (if unusual): No data available
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: No data available - Doses:
- 2630mg/kg
- No. of animals per sex per dose:
- 155
- Control animals:
- no
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 630 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Mortality observed
- Mortality:
- Mortality observed with 10-30 min due to respiratory failure
- Clinical signs:
- other: Tremors ,incoordination ,flaccid prostration
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- LD50 was consiidered to be 2630mg/kg body weight .When albino rats were treated with N, N, N-triethylethanaminium chloride (56-34-8)
- Executive summary:
Acute oral toxicity study was done in albino rat using test material N, N, N-triethylethanaminium chloride (56-34-8).155 animals were used. 40.6% test substance dissolved in distilled water to get required dose concentration. Maximum tolerated dose i.e.95-100 % animal survived was determined to be 750.0mg/kg .Clinical signslikeTremors, incoordination, flaccid prostrationwere observed. Mortality observed with 10-30 min due to respiratory failure at dose 2630mg/kg/bw .Hence LD50 was determined2630mg/kg body weight. When albino rats were treated with N, N, N-triethylethanaminium chloride (56-34-8)
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