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EC number: 941-893-5
CAS number: 15229-79-5
Table 1. Individual scores and mean scores for 24, 48 and
Number and Sex
Mean (24 – 72 h)
The study was performed to OECD TG 405 and EU Method
B.5 to assess the irritancy potential of the test material to the eye
following a single application in the New Zealand White rabbit. A volume
of 0.1 ml of the test material was placed into the conjunctival sac of
one eye of two animals. The other eye remained untreated and was used
for control purposes. The test was conducted in a stepwise manner
conducted singularly in accordance with the guideline. Assessment of
ocular damage/irritation was made approximately 1 hour and 24, 48 and 72
hours following treatment. A single application of the test material to
the non-irrigated eye of two rabbits produced diffuse corneal opacity,
iridial inflammation and moderate conjunctival irritation. Two treated
eyes appeared normal at the 72-Hour observation and one treated eye
appeared normal at the 14-Day observation. Under the
conditions of this study, the test item is not considered to be
irritating to the eye.
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