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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
17-01-2014 to 30-01-2014
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study performed under GLP. All relevant validity criteria were met.
Reason / purpose for cross-reference:
reference to same study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Deviations:
no
Qualifier:
according to guideline
Guideline:
other: OECD Test Guideline 113: Screening Test for Thermal Stability and Stability in Air
Deviations:
no
Remarks:
Screening for thermal stability under and inert atmosphere was conducted.
GLP compliance:
yes (incl. QA statement)
Remarks:
inspected: January 2013; signature: March 2013
Type of method:
effusion method: vapour pressure balance
Test no.:
#1
Temp.:
20 °C
Vapour pressure:
1.26 Pa
Test no.:
#2
Temp.:
25 °C
Vapour pressure:
2.12 Pa
Test no.:
#3
Temp.:
50 °C
Vapour pressure:
22.5 Pa

Preliminary Testing:

The DSC run indicated no exothermic or endothermic effects up to 300 °C using 12.57 mg sample inert atmosphere and sealed crucible and heating rate of +3 K/min.

 

Definitive Test:

The vapour pressure was measured in the range of 20 to 39 °C.

Table 1. Results Effusion Method: Vapour Pressure balance

Number

Temperature / °C

Vapour Pressure / Pa

1

18

0.98

2

19

1.14

3

21

1.46

4

23

1.73

5

25

2.11

6

27

2.56

 

From the Vapour Pressure as a function of the inverse temperature 1/T the Antonine constants were:

A = 13.5959

B = -3956.42

C = 273.15

 

Extrapolation of the measured VP curve to 20, 25 and 50 °C resulted in the following Vapour Pressures, respectively:

20 °C: VP = 1.26 Pa

25 °C: VP = 2.12 Pa

50 °C: VP = 22.5 Pa

Conclusions:
The vapour pressure of the test substance has been determined to be 1.26 Pa at 20 °C and 2.12 at 25 °C.
Executive summary:

The vapour pressure was determined using OECD TG 104, EU Method A.4 and US EPA OCSPP Guideline 830.7950 using the effusion : vapour pressure balance method. The test item vapour pressure was calculated by extrapolation of the measured vapour pressure curve encompassing seven temperatures under the conditions of the method. The calculated vapour pressure was 20°C: 1.26 Pa;  25°C: 2.12 Pa and 50°C: 22.5 Pa respectively.

Description of key information

Vapour Pressure: 1.26 Pa at 20 °C and 2.12 Pa at 25 °C, OECD TG 104 – Vapour Pressure Balance - Effusion Method, 2014

Key value for chemical safety assessment

Vapour pressure:
2.12 Pa
at the temperature of:
25 °C

Additional information

The vapour pressure was determined using OECD TG 104, EU Method A.4 and US EPA OCSPP Guideline 830.7950 using the effusion : vapour pressure balance method. The test item vapour pressure was calculated by extrapolation of the measured vapour pressure curve encompassing seven temperatures under the conditions of the method. The calculated vapour pressure was 20°C: 1.26 Pa;  25°C: 2.12 Pa and 50°C: 22.5 Pa respectively.