Registration Dossier

Administrative data

Endpoint:
toxicity to reproduction: other studies
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Remarks:
Secondary source reviewed, original document not reviewed.

Data source

Reference
Reference Type:
secondary source
Title:
Development of a flow cytometric method for mutagenicity testing in mouse germ cells.
Author:
Otto, F. J. and H. Oldiges
Year:
1986
Bibliographic source:
Wissenschaft und Umwelt, 1:15-30 (cited in ACGIH (2001). Documentation of TLVs).

Materials and methods

Test guideline
Guideline:
other: guideline not reported
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
mouse

Administration / exposure

Route of administration:
intraperitoneal
Doses / concentrationsopen allclose all
Dose / conc.:
200 other: mg/kg
Dose / conc.:
400 other: mg/kg

Results and discussion

Observed effects

o-Phenylenediamine increased the portion of diploid sperm in mice that were treated intraperitoneally with 200 or 400 mg/kg.

Applicant's summary and conclusion

Conclusions:
o-Phenylenediamine increased the portion of diploid sperm in mice that were treated intraperitoneally with 200 or 400 mg/kg.
Executive summary:

o-Phenylenediamine increased the portion of diploid sperm in mice that were treated intraperitoneally with 200 or 400 mg/kg.