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Toxicological information

Repeated dose toxicity: other routes

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Administrative data

Endpoint:
repeated dose toxicity: other route
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Remarks:
Secondary source reviewed, original document not reviewed.

Data source

Reference
Reference Type:
publication
Title:
No information
Author:
Galushka, A. I. et al.
Year:
1985
Bibliographic source:
Gig. Sanit., 6:78-79 (cited in the American Conference of Governmental Industrial Hygienists, Inc. Documentation of the Threshold Limit Values and Biological Exposure Indices. 6th ed. Volumes I, p. 1214, II, III. Cincinnati, OH: ACGIH, 1991).

Materials and methods

Test guideline
Guideline:
other: no guideline reported in secondary source
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat

Administration / exposure

Duration of treatment / exposure:
8 weeks
Doses / concentrations
Dose / conc.:
0.8 other: mg/kg
Details on study design:
o-Phenylenediamine was administered daily at 0.8 mg/kg body weight to rats for 8 weeks (route, sex, number, and animal strain not cited).

Results and discussion

Results of examinations

Details on results:
o-Phenylenediamine decreased the number of erythrocytes and increased the serum activities of the alkaline phosphatase, aldolase, and alanine and aspartate aminotransferases.

Effect levels

Dose descriptor:
NOAEL
Remarks on result:
not determinable
Remarks:
no NOAEL identified

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
o-Phenylenediamine decreased the number of erythrocytes and increased the serum activities of the alkaline phosphatase, aldolase, and alanine and aspartate aminotransferases.
Executive summary:

o-Phenylenediamine decreased the number of erythrocytes and increased the serum activities of the alkaline phosphatase, aldolase, and alanine and aspartate aminotransferases.