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EC number: 202-430-6 | CAS number: 95-54-5
Until 72 hours post application the Conjunctiva of all animals clear swelling to swelling with more than half-closed eyelids as well as vaguely strongly red coloring showed 1 hour. The iris of the animals were turned red. The cornea showed scattered to easily recognizably shining through opacity areas. 7 days post application were the Conjunctiva of the animals clearly swollen and vaguely crimson to strongly red colored. The iris of an animal was turned red. With an animal the cornea showed scattered opacity areas. In addition 1 hour to 7 days post application partial clear-browner to white-slimy discharge as well as brown and/or white discolorations and bleedings of the Conjuctiva and nictitating membranes were observed. 14 days post application all the irritation characteristics were reversible.
From the numerically evaluated individual studies at the observation times after 24, 48 and 72 hours the following average values were computed:
An eye irritation test was performed in accordance with OECD Guideline 405. On 3 rabbits were uniquely applied 100 mg o-Phenylenediamine in the conjuctival sack of the left eye. The untreated eye served in each case as control. The evaluations of the eyes took place 1, 24, 48 and 72 hours after application of the test substance. For the evaluation dates 24 and 72 hours additionally after instillation of a drop Fluorescein sodium solution (0.01%) was examined the cornea under UV light for damage. Damage to the cornea, the iris and the connected skin was numerically evaluated. All other changes were recorded. Since after 72 hours still effects at the eye were present, an additional finding collection took place on 7 and 14 days. The test substance was irritating to the eye.
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