Registration Dossier

Administrative data

Endpoint:
epidemiological data
Type of information:
not specified
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Cohort mortality study of retired fur dyers and dressers.
Author:
Haring, M., Walrath, J. and Waxweiler, R.
Year:
1982
Bibliographic source:
Am. J. Epidemiol., 116(3):570.

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Results:
A cohort of 1018 fur dyers and dressers pensioned between 1952 and 1977 was identified. Death certificates were obtained for 97.7% of the 540 deaths. Comparisons with the population revealed significantly higher SMRs for all malignant neoplasms combined among all fur workers.  Dyers experienced elevated mortality from stomach cancer. Dressers had a three-fold increase in deaths from lung cancer. Fur dyers had exposure to oxidative dye components including toluenediamine and phenylenediamine.  Dressers have limited dye exposure and are mainly exposed to tanning chemicals and wood dust.

Applicant's summary and conclusion

Conclusions:
Comparisons with the population revealed significantly higher SMRs for all malignant neoplasms combined among all fur workers.  Dyers experienced elevated mortality from stomach cancer. Dressers had a three-fold increase in deaths from lung cancer.
Executive summary:

A cohort of 1018 fur dyers and dressers pensioned between 1952 and 1977 was identified. Death certificates were obtained for 97.7% of the 540 deaths. Comparisons with the population revealed significantly higher SMRs for all malignant neoplasms combined among all fur workers.  Dyers experienced elevated mortality from stomach cancer. Dressers had a three-fold increase in deaths from lung cancer. Fur dyers had exposure to oxidative dye components including toluenediamine and phenylenediamine.  Dressers have limited dye exposure and are mainly exposed to tanning chemicals and wood dust.