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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from authoritative database

Data source

Referenceopen allclose all

Reference Type:
other: authoritative database
Title:
Acute toxicity test of test chemical in rat.
Author:
U.S. National Library of Medicine
Year:
2018
Bibliographic source:
Chemidplus Database,U.S. National Library of Medicine,2018
Reference Type:
secondary source
Title:
Acute toxicity test in rat
Author:
RTECS
Year:
2018
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances),2018

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Acute toxicity test of test chemical with rat.
GLP compliance:
not specified
Test type:
other: no data
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): SNS (sodium 2-naphthalenesulfonate)
- Molecular formula: C10H7NaO3S
- Molecular weight: 230.23 g/mol
- Substance type: Organic
- Physical state: solid
- Smiles: c1ccc2cc(ccc2c1)S(=O)(=O)[O-].[Na+]
- InChI: 1S/C10H8O3S.Na/c11-14(12,13)10-6-5-8-3-1-2-4-9(8)7-10;/h1 7H,(H,11,12,13);/q;+1/p-1

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
no data
Doses:
13900 mg/kg bw
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
no data
Statistics:
no data

Results and discussion

Preliminary study:
no data
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
13 900 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality was observed
Mortality:
50% mortality was observed at dose 13900 mg/kg bw
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data
Other findings:
no data

Applicant's summary and conclusion

Interpretation of results:
other: not classified
Conclusions:
The lethal concentration (LD50) value for acute oral toxicity test was considered to be 13900 mg/kg bw,when rats were treated with test chemical orally.
Executive summary:

Acute oral toxicity study was performed in rats using test chemical.50% mortality was observed at dose13900 mg/kg bw. Hence,LD50 value was considered to be 13900 mg/kg bw,when rats were treated with test chemical orally.