2-Propenal, 2-fluoro-3-(4-morpholinyl)-, (Z)-

Melting point / freezing point

Administrative data

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2018-07-11 to 2018-10-22

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Test guideline 3

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7200 (Melting Point / Melting Range)

GLP compliance:

no

Type of method:

capillary method

Test material

Test material information

Constituent 1

Reference substance name:

(2Z)-2-fluoro-3-(morpholin-4-yl)prop-2-enal

EC Number:

813-789-9

Cas Number:

152873-67-1

Molecular formula:

C7H10FNO2

IUPAC Name:

(2Z)-2-fluoro-3-(morpholin-4-yl)prop-2-enal

Test material form:

solid

Specific details on test material used for the study:

Name: (2Z)-2-Fluor-3-(morpholin-4-yl)acrylaldehyd (FMA)
Lot Number: BXR82PT
CAS No.: 152873-67-1
Sponsor No. 2950024288
Aggregate State at Room Temperature: Solid
Colour: Brown
Expiry Date: November 01, 2018
Storage Conditions at Test Facility: At 20 °C ± 5 °C, in the dark

Results and discussion

Melting / freezing point

Key result

Melting / freezing pt.:

>= 101.3 - <= 108.4 °C

Atm. press.:

ca. 1 013 hPa

Applicant's summary and conclusion

Conclusions:

In conclusion (2Z)-2-Fluor-3-(morpholin-4-yl)acrylaldehyd (FMA) melted in the range of 101.3 °C to 108.4 °C (374.4 K to 381.6 K).

Executive summary:

Title:

(2Z)-2-Fluor-3-(morpholin-4-yl)acrylaldehyd (FMA): Determination of the Melting Point / Melting Range

Purpose:

The purpose of this study was to evaluate the melting point or melting range of (2Z)-2-Fluor-3-(morpholin-4-yl)acrylaldehyd (FMA) by the capillary method using an electronic controlled heating system.

Guidelines/Recommendations:

This study was based on the procedures indicated by the following internationally accepted methods:

-Commission Regulation (EC) No 440/2008 laying down test methods pursuant to Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) (originally published as Council Regulation (EC) No 440/2008, corrigendum according to Official Journal of the European Union (EN) dated June 3, 2008, L 143/55), Annex V, Part A, A.1.: “Melting /Freezing Temperature”, Official Journal of the European Union, L 142, Volume 51, 31 May 2008

-Organization for Economic Co-operation and Development (OECD), Guidelines for Testing of Chemicals, Guideline No.: 102, “Melting Point/Melting Range”, adopted July 27, 1995

-Product Properties Test Guideline of the United States Environment Protection Agency (EPA), OPPTS 830.7200 Melting Point / Melting Range, March 1998

Results:           

The determination of the melting point was performed by visual judgement using the capillary method. In the preliminary tests the test item starts melting at 97 °C. The test item showed all five stages of melting. The melting started at 101.3 °C (stage A). At 108.4 °C the last stage E of melting could be visual observed. At the end of the test the test item was liquid and red.

Conclusion:

In conclusion, the test item (2Z)-2-Fluor-3-(morpholin-4-yl)acrylaldehyd (FMA) melted in the range of 101.3 °C to 108.4 °C (374.4 K to 381.6 K). This study is classified acceptable and satisfies the guideline requirements for melting point studies.