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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Animal experimental study, predates implementation of GLP and/or development of study guidelines, limitations in design and/or reporting but otherwise adequate for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1974
Report Date:
1974

Materials and methods

Principles of method if other than guideline:
According to BASF-internal standard: Two white Vienna rabbits were treated for 1, 5 and 15 minutes and for 20 hours using occlusive conditions. An application site of 2.5 x 2.5 cm was covered with moistened test substance. After the application time, the skin was washed. Animals were observed for 8 days.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Dioxyäthyl-anilin

Test animals

Species:
rabbit
Strain:
Vienna White
Details on test animals and environmental conditions:
- Weight at study initiation: female 2.77 kg, male 2.91 kg

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
other:
Controls:
other: untreated skin of the same animal
Amount / concentration applied:
80% aqueous test substance preparation.
Duration of treatment / exposure:
1, 5, 15 min, and 20 h
Observation period:
8 days
Number of animals:
2
Details on study design:
Application area: 2.5 x 2.5 cm2
After the application time the skin was washed with 50% Lutrol/water

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24 h
Score:
0
Max. score:
4
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24 h
Score:
0
Max. score:
4
Irritant / corrosive response data:
No irritation was observed after 24 hours and 8 days on the animals exposed for 1, 5, 15 minutes and 20 hours.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information