Registration Dossier
Registration Dossier
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EC number: 222-217-1 | CAS number: 3388-04-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 962
- Report date:
- 1962
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-(3,4-epoxycyclohexyl)ethyltrimethoxysilane
- EC Number:
- 222-217-1
- EC Name:
- 2-(3,4-epoxycyclohexyl)ethyltrimethoxysilane
- Cas Number:
- 3388-04-3
- Molecular formula:
- C11H22O4Si
- IUPAC Name:
- trimethoxy[2-(7-oxabicyclo[4.1.0]hept-3-yl)ethyl]silane
- Details on test material:
- - Name of test material (as cited in study report): 3,4-epoxy cyclohexylethyl trimethoxysilane
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: 'the rabbits were produced locally'
- Age at study initiation: 3-5 months
- Weight at study initiation: mean 2.5 kg
- Diet: 'Rockland rabbit ration'
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: trunk
No further detail included in the test report. - Duration of exposure:
- 24h
- Doses:
- 10 and 5 ml/kg
- No. of animals per sex per dose:
- 5 males
- Control animals:
- not specified
- Details on study design:
- No details given in this very brief summary.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 6.3 mL/kg bw
- Remarks on result:
- other: Equivalent to 6741 mg/kg (calculated with density of 1.07 g/cm3)
- Mortality:
- Deaths occurred on the first and second day after application.
- Clinical signs:
- other: Three rabbits had convulsions on the first and second day after application.
- Gross pathology:
- Hemorrhage and congestion of the lungs, pale mottled livers with prominent acini, pale spleens, and pale mottled kidneys. Bloody discharge was present around the nose and mouth of two animals.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- An acute dermal LD50 of 6.30 ml/kg bw (equivalent to 6741 mg/kg bw based on a density of 1.07 g/cm3), is reported in a study conducted according to a protocol equivalent to guideline but not in compliance with GLP.
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