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Physical & Chemical properties

Melting point / freezing point

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Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
August 10, 2016 - October 21, 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
GLP compliance:
no
Type of method:
differential scanning calorimetry
Specific details on test material used for the study:
Internal sample code: 2929564-001
Purity: 100.3% w/w
Batch number: 2510468
Key result
Melting / freezing pt.:
ca. 67.2 °C
Decomposition:
yes
Decomp. temp.:
ca. 234.2 °C

Results

First test

Using an analytical balance, 1.5000 mg of test item were weighed into the aluminium standard 40mL crucible, the test was performed in a temperature rangefrom 25 to 300°C, with a heating rate of 7°C/min.

 

The following behaviour was observed:

44.5 – 75.3°C            Endothermicreaction showing a melting transition

75.3 – 234.2°C          The baseline remains stable and no boiling or decomposition phenomena were detected.

234.2 – 289.9 °C       Exothermicreaction showing a possible decomposition behaviour of the test item.

Second test

Since the first test didn’t show a well-defined melting transition, in order to obtain a more reliable value of melting point, a second test was run in a temperature rangefrom 30 to 100°C, lowering the heating rate to 1°C/min.

 

The following behaviour was observed:

 54.6 – 73.1°C            Endothermic reaction showing a well-defined melting transition of the test item at 67.2°C.

 

Conclusions:
From the obtained experimental data according to the A.1 method in Council Regulation (EC) No 440/2008 of 30 May 2008, OECD Guidelines No. 102, it can be concluded that Delmopinolo HCl sample melts at 67.2°C, without concurrent decomposition; a decomposition phenomena is occurred at 234°C.
Executive summary:

Delmopinolo HCl sample melts at 67.2°C.

Description of key information

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
67.2 °C

Additional information

From the obtained experimental data according to the A.1 method in Council Regulation (EC) No 440/2008 of 30 May 2008, OECD Guidelines No. 102, it can be concluded that Delmopinolo HCl sample melts at 67.2°C, without concurrent decomposition; a decomposition phenomena is occurred at 234°C.