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Environmental fate & pathways

Biodegradation in water: screening tests

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Key value for chemical safety assessment

Biodegradation in water:
under test conditions no biodegradation observed

Additional information

Transaminase enzyme is produced by a water based fermentation process using carbohydrates as a carbon source and trace ingredients required for the bacteria to grow and reproduce. The process requires that the various ingredients are water soluble and non-toxic to the bacteria. The fermentation and downstream processing conditions result in an enzyme and fermentation by-products that are water soluble and biodegradable. There are no sources of substances with octanol water partition coefficients (log Kow > 4) that would represent a potential to persist in the environment. Enzymes, in general, and Transaminase enzyme in particular, are large macromolecules and as such do not represent a bioconcentration potential.

Standard ready biodegradability tests are not appropriate for UVCB substances such as transaminase enzyme as these are complex mixtures. These tests are more appropriate for individual substances. However, OECD ready biodegradability tests have been conducted on lipases, cellulases and amylase with results(92 to 99% DOC removal) that surpass the OECD threshold limit of 70% DOC removal (Bergman, 1997).