Registration Dossier
Registration Dossier
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EC number: 701-138-0 | CAS number: 242482-67-3
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No acute toxicity on freshwater invertebrates observed up to the tested limit concentration of 400 mg/L (analytically verified).
Key value for chemical safety assessment
Additional information
Acute toxicity on freshwater invertebrates was tested using Daphnia magna in a reliable (reliability category 1) study performed with the submission substance 6-(isononanoylamino)hexanoic acid, compound with 2,2’,2’’-nitrilotriethanol compliant to GLP and according to relevant test guidelines. Test item concentrations 400, 200, 100, 50, and 25 mg were analytically confirmed to be on average 102 % of nominal during the 48 hour test period. No immobilisation of the test animals was observed in the control and for the test item up to and including the highest test item concentration of 400 mg/L.
As regards marine invertebrates, two studies with the submission substance 6-(isononanoylamino)hexanoic acid, compound with 2,2’,2’’-nitrilotriethanol performed in close temporal succession on the marine invertebrate Acartia tonsa (herbivore copepod) are available. The studies were performed according to ISO 14669:1999(E) draft guideline but are insufficiently documented (e.g. no information on number of test organism used / affected per concentration, no data on statistical evaluation, no data on test item purity) and equivocal especially in regard to derived (no)effect concentrations. Thus both studies are not reliable (reliability category 3). Concentrations between 2 mg/L and 20 mg/L respectively 35.6 mg/L (second study) were tested. At all concentrations some immobilization was observed (including the control for the second study with 5% and the control in the range finding test of the first study with 90% immobilization), but a dose-response relationship was seen at least for the 48 h-values in both final studies. Reported EC50-values are 5.9 (first study) and 10.5 mg/L (second study). Thus marine invertebrates may be more susceptible to 6-(isononanoylamino)hexanoic acid, compound with 2,2’,2’’-nitrilotriethanol than freshwater organisms, but no firm conclusions can be drawn from these two unreliable studies.
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