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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: 84/449/EWG, B.3
GLP compliance:
yes
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
431-460-4
EC Name:
-
Cas Number:
10061-02-6
Molecular formula:
C3H4Cl2
IUPAC Name:
(1E)-1,3-dichloroprop-1-ene
Test material form:
liquid
Details on test material:
Batch no: TR 88001
Also know as ST088/098

Test animals

Species:
other: rat, Fischer 344

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
other: No vehicle.
Duration of exposure:
24 h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1 575 mg/kg bw
95% CL:
1 163 - 3 111
Remarks on result:
other: Slope of the mortality curve: 2.5
Mortality:
Male: 488 mg/kg bw; Number of animals: 5; Number of deaths: 1
Male: 781 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 1250 mg/kg bw; Number of animals: 5; Number of deaths: 1
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 4
Female: 488 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 781 mg/kg bw; Number of animals: 5; Number of deaths: 1
Female: 1250 mg/kg bw; Number of animals: 5; Number of deaths: 2
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 3
Clinical signs:
other: Signs of toxicity related to dose levels: Principle signs of reaction to the treatment observed within 5 hours of topical application were voiding of soft faeces or diarrhoea, lethargy and, particularly at the high dose levels, increased lachrymation.
Gross pathology:
Effects on organs:
Gastro-intestinal irritation and petechiae on the thymis.
One female rat killed on day 14 showed local irritation of
the stomach. No other macroscopic abnormalities
abnormalities were found during necropsy of the rats that
survived treatment.


Necropsy of decedents revealed similar macroscopic
abnormalities at each dose level. Common pathological
changes included fluid contents, inflamation and/or
heamorrhage of the stomach, petechiae on the thymus and
fluid contents of the intestinal tract. Other isolated
findings included exaggerated hepatic lobular pattern, dark
spleen, pallor of the kidneys and the presence of blood in
the urine.
Other findings:
Signs of toxicity (local):
Sites of application of the test substance generally showed
erythema and oedema after removal of the dressings on day 2.
Erythema was the only common, persistent reaction to
treatment observed from day 3. All signs of reaction to
treatment resolved by day 7.

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria