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EC number: -
CAS number: -
EC50 (6 h) > 10 mg/L (nominal); read-acrossEC50 (3 h) > 1000 mg/L for the respiration of activated sludge microorganisms (OECD 209); read-across
One study, investigating the toxicity of Pentaerythritol
tetraesters of n-decanoic, n-heptanoic, n-octanoic and n-valeric acids
(CAS 68424-31-7), was used as read across for Fatty acids, C5-10 (linear
and branched), tetraesters with pentaerythritol. This read-across
substance is structurally and compositionally related to Fatty acids,
C5-10 (linear and branched), tetraesters with pentaerythritol.
This cell multiplication inhibition test (Comber and Coleman,
1991) according to Bringman and Kuehn (1980) determined EC10 and EC50 (6
h) > 10 mg/L (nominal). No inhibition on the growth of Pseudomonas
putida was observed at the tested concentration (10 mg/L nominal).
Furthermore, the biodegradation tests exhibit the readily
biodegradability of the test substance. Therefore, the sensitive single
species as well as the activated sludge test shows no inhibition and a
disturbance in the biodegradation process of a sewage treatment plant is
In accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a
further read across to two structurally related category members
decanoic acid, mixed esters with heptanoic acid, octanoic acid,
pentaerythritol and valeric acid (71010-76-9), and fatty acids, C8-10
(even numbered), di-and triesters with propylidynetrimethanol (CAS
11138-60-6) was conducted to support the above mentioned data on CAS
68424-31-7. This read-across is justified in detail in the overall
summary (IUCLID chapter 6.1) and within the category justification in
IUCLID Section 13. In this case of read-across, the best suited (highest
degree of structural similarity, nearest physico-chemical properties)
read-across substances were used for the assessment. The fatty acid
chain length of C5 – C10 of the first read-across substance is similar
to that of the target substance and both substances contain the same
alcohol (pentaerythritol) and are tetra-esters. The remaining polyol
ester category member has a different alcohol component (TMP) but chain
lengths between C8 and C10.
The first read across study investigating toxicity to aquatic
microorganisms was conducted with decanoic acid, mixed esters with
heptanoic acid, octanoic acid, pentaerythritol and valeric acid (CAS No.
71010-76-9) under static conditions according to OECD 209 (Dickinson,
2008). In this study non-adapted activated sludge obtained from a
domestic sewage treatment plant was used as inoculum. Test
concentrations of 10, 100 and 1000 mg/L were prepared. Test substance
was added directly to the test vessels. The test substance did not
inhibit the respiration rate of activated sludge microorganisms at any
of the concentrations employed in the test. Hence, the 3 h-EC50 was
determined to be > 1000 mg/L based on the nominal test concentration.
Therefore, it can be concluded that the test substance will not exhibit
effects on the respiration rate of microorganisms.
The second read across study with fatty acids, C8-10 (even
numbered), di-and triesters with propylidynetrimethanol (CAS 11138-60-6)
was conducted according to OECD 209 investigating aquatic microorganisms
(Kuttler, 1998). In this study activated sludge obtained from a domestic
sewage treatment plant was used as inoculum. A test concentration of
10000 mg/L was prepared and was added directly to the test vessels. The
test substance did not inhibit the respiration rate of activated sludge
microorganisms, the 3 h-EC50 was therefore determined to be > 10000 mg/L
based on the nominal test concentration. Therefore it can be concluded
that the test substance will not exhibit effects on the respiration rate
Based on these results from structurally related read-across
substances which are characterized by a similar ecotoxicological
profile, it can be concluded that fatty acids, C5-10 (linear and
branched), tetraesters with pentaerythritol (CAS 68424-31-7)will not
have adverse effects on the respiration rate of microorganisms,
therefore, a disturbance in the biodegradation process of a sewage
treatment plant is not anticipated. As it can be seen in the data matrix
of the category justification in section 13 and the overall endpoint
summary IUCLID 6.1, all reliable data in the polyol esters category
support this hazard assessment by showing a consistent pattern of
results, i.e. no microbial inhibition and no toxic effects were observed
to aquatic organisms up to the limit of water solubility.
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