Registration Dossier

Physical & Chemical properties

Melting point / freezing point

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
03 September 2014 to 16 November 2014
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Version / remarks:
2008
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
method to determine freezing temperature
Key result
Melting / freezing pt.:
< -20 °C

Determination 1

Observations: The test material did not freeze during cooling.

Result: Freezing temperature: <-20 °C (<253 K).

 

Determination 2

Observations: The test material did not freeze during cooling.

Result: Freezing temperature: <-20 °C (<253 K).

Conclusions:
Under the conditions of this study the freezing temperature of the test material has been determined to be less than -20 °C (<253 K).
Executive summary:

The melting/ freezing temperature of the test material was investigated in accordance with the standardised guidelines OECD 102 and EU Method A.1., under GLP conditions.

An aliquot (approximately 15 mL) of test material was placed into a test tube containing a thermometer and a connection to a nitrogen line. A wire loop with which the sample could be agitated was placed inside the tube to ensure sample homogeneity during cooling. The test tube was surrounded by a glass jacket and then placed into a large beaker containing a dry ice/acetone mixture. The temperature and observations of the test material were recorded approximately every 30 seconds.

The test material was sampled under nitrogen and remained under nitrogen throughout the test. The dry ice/acetone bath was maintained until the sample temperature had reached below -20 °C or until the test material solidified. The determination was carried out in duplicate.

In both determinations the test material did not freeze during cooling.

Under the conditions of this study the freezing temperature of the test material has been determined to be less than -20 °C (<253 K).

Description of key information

Under the conditions of this study the freezing temperature of the test material has been determined to be less than -20 °C (<253 K).

Key value for chemical safety assessment

Additional information

The melting/ freezing temperature of the test material was investigated in accordance with the standardised guidelines OECD 102 and EU Method A.1., under GLP conditions. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

An aliquot (approximately 15 mL) of test material was placed into a test tube containing a thermometer and a connection to a nitrogen line. A wire loop with which the sample could be agitated was placed inside the tube to ensure sample homogeneity during cooling. The test tube was surrounded by a glass jacket and then placed into a large beaker containing a dry ice/acetone mixture. The temperature and observations of the test material were recorded approximately every 30 seconds.

The test material was sampled under nitrogen and remained under nitrogen throughout the test. The dry ice/acetone bath was maintained until the sample temperature had reached below -20 °C or until the test material solidified. The determination was carried out in duplicate.

In both determinations the test material did not freeze during cooling.

Under the conditions of this study the freezing temperature of the test material has been determined to be less than -20 °C (<253 K).